A Radiological Scoring System for Differentiation between Enchondroma and Chondrosarcoma

Miwa, Shinji; Yamamoto, Norio; Hayashi, Katsuhiro; Takeuchi, Akihiko; Igarashi, Kentaro; Tada, Kazuhiro; Yonezawa, Hirotaka; Morinaga, Sei; Araki, Yoshihiro; Asano, Yohei; Saito, Shiro; Okuda, Miho; Taki, Junichi; Ikeda, Hiroko; Nojima, Takayuki; Tsuchiya, Hiroyuki

doi:10.3390/cancers13143558

Cited by 9 publications

(10 citation statements)

References 34 publications

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“…In the foot, chondrosarcoma most commonly involves the calcaneum, the talus and the first metatarsal bone. 3,4 Unlike this our case presented with lesion in proximal phalynx of the left great toe and the X-ray showed expansile septated lytic lesion with cortical breach on medial aspect, on plain radiography. On MRI altered signal intensity expansile lytic lesion involving proximal phalynx of left great toe was seen T2 weighted image showed hyperintense signal, mimicking osteoclatoma radiologically.…”

Section: Discussionmentioning

confidence: 51%

“…3 It is seen that most pedal chondrosarcomas are primary tumors as seen in our case, rather than secondary to a preexisting cartilaginous lesions like enchondroma, osteochondroma etc. [4][5][6] Females are slightly more susceptable for phalangeal chondrosarcoma in comparison to other locations in the body and most common presentation is pain and swelling.…”

Section: Discussionmentioning

confidence: 99%

“…X-ray Radiography of chondrosarcoma shows lytic lesion with popcorn like calcification, however CT scan and MRI are helpful modalities in determining the extent of tumor. 4 We report an unusual presentation of chondrosarcoma of distal phalynx of the great toe.…”

Section: Introductionmentioning

confidence: 92%

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Chondrosarcoma of the great toe clinically mimicking osteoclastoma-An unusual presentation

Akhtar¹,

Usmani

Lubna³

et al. 2023

JDPO

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Chondrosarcoma is cartilage forming neoplasm which mostly occurs in pelvis, femur and humerous. Chondrosarcoma is rare in the foot and the involvement of phalanges is extremely rare. It is a malignant neoplasm which mimics various epiphysial tumors clinically and radiologically, so histopathology is the gold standard for confirming the diagnosis. We report an unusual case of Grade II Chondrosarcoma in a 60 years old male, who complained of swelling and pain in left great toe for the past two years, which clinically mimicked Osteoclastoma. Imprint smear from swelling in the left great toe showed scattered mononucleated to binucleated oval to plump to polygonal cells with coarse chromatin and moderate eosinophilic cytoplasm in a chondromyxoid background suggestive of malignancy with differentials of Osteosarcoma and Chondrosarcoma. Histomorphology with immunohistochemistry led to the confirmation of diagnosis of this tumor at a rare site.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

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Chondrosarcoma of the great toe clinically mimicking osteoclastoma-An unusual presentation

Akhtar¹,

Usmani

Lubna³

et al. 2023

JDPO

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“…29,31 Lesions with a non-specific periosteal reaction were also considered.- Cortical lysis was defined by the presence of bone lysis attaining the full thickness of the cortical bone.- Endosteal scalloping was considered present when endosteal bone lysis attained more than 2/3 of the normal cortical thickness. 32 - Presence of pathologic fracture was considered to be present when a fracture line with cortical interruption was seen adjacent to a lytic bone lesion.- Lesion mineralization was classified as osteoid type, chondroid type, other types of mineralization (including the fibrous type), and non-mineralized. 31 …”

Section: Methodsmentioning

confidence: 99%

Initial Characterization of Focal Bone Lesions with Conventional Radiographs or Computed Tomography: Diagnostic Performance and Interobserver Agreement Assessment

et al. 2022

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Objectives: To ascertain the role of CT and conventional radiographs for the initial characterization of focal bone lesions. Methods: Images from 184 patients with confirmed bone tumors included in an ethics committee-approved study were retrospectively evaluated. The reference for benign-malignant distribution was based on histological analysis and long-term follow-up. Radiographs and CT features were analyzed by 2 independent musculoskeletal radiologists blinded to the final diagnosis. Lesion margins, periosteal reaction, cortical lysis, endosteal scalloping, presence of pathologic fracture, and lesion mineralization were evaluated. Results: The benign-malignant distribution in the study population was 68.5–31.5% (126 benign and 58 malignant). In the lesions that could be seen in both radiographs and CT, the performance of these methods for the benign-malignant differentiation was similar (accuracy varying from 72.8% to 76.5%). The interobserver agreement for the overall evaluation of lesion aggressiveness was considerably increased on CT compared to radiographs (Kappa of .63 vs .22). With conventional radiographs, 18 (9.7%) and 20 (10.8%) of the lesions evaluated were not seen respectively by readers 1 and 2. Among these unseen lesions, 50%–61.1% were located in the axial skeleton. Compared to radiographs, the number of lesions with cortical lysis and endosteal scalloping was 26–34% higher with CT. Conclusion: Although radiographs remain the primary imaging tool for lesions in the peripheral skeleton, CT should be performed for axial lesions. CT imaging can assess the extent of perilesional bone lysis more precisely than radiographs with a better evaluation of lesion fracture risk.

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“…Radiomics nomogram based on non-enhanced MRI showed hopeful performance in distinguishing enchondroma from chondrosarcomas, but their performance in differentiating high-grade chondrosarcomas from low-grade chondrosarcomas has not been sufficiently proven ( 14 ). CT has been less commonly used to grade cartilaginous tumors than MRI, and no study based on CT texture analysis has been report ( 15 ). However, MRI has been applied to analyze cartilaginous tumors but is less effective for visualizing calcification or bone destruction than CT ( 16 , 17 ).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of CT- and MRI-Based Texture Analysis and Imaging Findings for Grading Cartilaginous Tumors in Long Bones

Deng

Chen

et al. 2021

Front. Oncol.

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ObjectiveTo confirm the diagnostic performance of computed tomography (CT)-based texture analysis (CTTA) and magnetic resonance imaging (MRI)-based texture analysis for grading cartilaginous tumors in long bones and to compare these findings to radiological features.Materials and MethodsTwenty-nine patients with enchondromas, 20 with low-grade chondrosarcomas and 16 with high-grade chondrosarcomas were included retrospectively. Clinical and radiological information and 9 histogram features extracted from CT, T1WI, and T2WI were evaluated. Binary logistic regression analysis was performed to determine predictive factors for grading cartilaginous tumors and to establish diagnostic models. Another 26 patients were included to validate each model. Receiver operating characteristic (ROC) curves were generated, and accuracy rate, sensitivity, specificity and positive/negative predictive values (PPV/NPV) were calculated.ResultsOn imaging, endosteal scalloping, cortical destruction and calcification shape were predictive for grading cartilaginous tumors. For texture analysis, variance, mean, perc.01%, perc.10%, perc.99% and kurtosis were extracted after multivariate analysis. To differentiate benign cartilaginous tumors from low-grade chondrosarcomas, the imaging features model reached the highest accuracy rate (83.7%) and AUC (0.841), with a sensitivity of 75% and specificity of 93.1%. The CTTA feature model best distinguished low-grade and high-grade chondrosarcomas, with accuracies of 71.9%, and 80% in the training and validation groups, respectively; T1-TA and T2-TA could not distinguish them well. We found that the imaging feature model best differentiated benign and malignant cartilaginous tumors, with an accuracy rate of 89.2%, followed by the T1-TA feature model (80.4%).ConclusionsThe imaging feature model and CTTA- or MRI-based texture analysis have the potential to differentiate cartilaginous tumors in long bones by grade. MRI-based texture analysis failed to grade chondrosarcomas.

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A Radiological Scoring System for Differentiation between Enchondroma and Chondrosarcoma

Cited by 9 publications

References 34 publications

Chondrosarcoma of the great toe clinically mimicking osteoclastoma-An unusual presentation

Chondrosarcoma of the great toe clinically mimicking osteoclastoma-An unusual presentation

Initial Characterization of Focal Bone Lesions with Conventional Radiographs or Computed Tomography: Diagnostic Performance and Interobserver Agreement Assessment

Diagnostic Value of CT- and MRI-Based Texture Analysis and Imaging Findings for Grading Cartilaginous Tumors in Long Bones

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