A randomised clinical trial to assess maintenance of gingival health by a novel gel to foam dentifrice containing 0.1%w/w o-cymen-5-ol, 0.6%w/w zinc chloride

Kakar, Ashish; Newby, Evelyn; Ghosh, Siddhartha Sankar; Butler, Andrew; Bosma, Mary Lynn

doi:10.1111/j.1875-595x.2011.00045.x

Cited by 13 publications

(25 citation statements)

References 5 publications

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“…Dental plaque plays a major role in the aetiology of periodontal disease. The mainstay of preventing periodontal disease is the control of plaque and thus the prevention of plaque induced gingivitis (1). …”

Section: Introductionmentioning

confidence: 99%

Preliminary Antiplaque Efficacy of <i>Aloe Vera</i> Mouthwash on 4 Day Plaque Re -Growth Model: Randomized Control Trial

Gupta¹,

Gupta²,

Bhaskar³

et al. 2014

Ethiop J Health Sci

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BackgroundPalmaris longus, being the most variable muscle of the upper extremity is generally considered important morphologically rather than functionally. The palmar aponeurosis represents the distal part of the tendon of Palmaris longus.Case DetailsWe report here a unique case of palmaris longus presenting variation distally as its tendon divides to gain multiple attachments with the fascia covering the abductor pollicis brevis, flexor retinaculum and the tendon of flexor carpi ulnaris. In addition, it also continues as palmar aponeurosis as its normal course.ConclusionPresence of this kind of variation might result in compression of the median and ulnar nerves and may aggravate the complications in case of inflammation of palmar aponeurosis thus mimicking the manifestations of Dupuytren's contracture.

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Section: Introductionmentioning

confidence: 99%

Preliminary Antiplaque Efficacy of <i>Aloe Vera</i> Mouthwash on 4 Day Plaque Re -Growth Model: Randomized Control Trial

Gupta¹,

Gupta²,

Bhaskar³

et al. 2014

Ethiop J Health Sci

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“…The level of agreement between the initial and repeat MGI was calculated using a Kappa coefficient. The intra‐examiner kappa scores were 0.96 (95% CI 0.95, 0.96) for Study I 3 and 0.95 (95%CI 0.94, 0.96) for Study II 4 . These two results demonstrate excellent 8 repeatability and consistency of the examiners scoring.…”

Section: Discussionmentioning

confidence: 60%

Maintenance of gingival health – a measure based on clinical indices

Butler

Targett

Bosma

2011

International Dental Journal

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Objectives: To introduce a variable which directly measures maintenance of gingival health. Design: The maintenance of gingival health index (MGHI) is based on the change in score at each tooth site compared to a reference visit for a clinical index (eg MGI or BI). For a subject the number of sites that (1) improve-NDEC, (2) show no change-NNOCHG or (3) worsen-NINC in score are determined. Then the MGHI for a subject is defined as (NDEC + NNOCHNG) ⁄ NINC. Results: This method was applied to two clinical studies and both studies demonstrated significantly better maintenance of gingival health in those subjects who received the experimental 0.1% w ⁄ w o-cymen-5-ol ⁄ 0.6% w ⁄ w ZnCl 2 dentifrice compared to the 0.204% w ⁄ w sodium fluoride control dentifrice based on a gingival and a bleeding clinical index. Conclusion: The MGHI is a useful measure to assess the maintenance of gingival health. It is very applicable to the maintenance of gingival health study designs as it directly looks at a measurement of maintaining the health of tooth sites. It also provides a meaningful measure of the relative effectiveness of dentifrice products to the dental practitioner.

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“…Zinc products have been evaluated for plaque control, but also focused on halitosis control [35-39; [42]. Some products have demonstrated some efficacy on plaque [43] and gingivitis [44,45]: a 12-week study reported a 20.7% reduction in plaque and 38.1% in gingivitis, of a 0.1% o-cymen-5-ol and 0.6% zinc chloride dentifrice, when compared to a control dentifrice (p < 0.0001) [44]; however, only one 6-month trial is available [45], demonstrating reductions of 25.3% in plaque and 18.8% in gingivitis, when compared to the placebo. In summary, when they are used as single ingredients, they have limited effects on plaque; but they may also be used in combination with other active agents (triclosan, CPC, CHX), which may improve substantivity and efficacy.…”

Section: Metal Salts: Zinc Saltsmentioning

confidence: 99%

Antiplaque and Antigingivitis Toothpastes

Sanz

Serrano

Iniesta

et al. 2013

Monographs in Oral Science

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Dentifrices are a general term used to describe preparations that are used together with a toothbrush with the purpose to clean and/or polish the teeth. Active toothpastes were first formulated in the 1950s and included ingredients such as urea, enzymes, ammonium phosphate, sodium lauryl sarcosinate and stannous fluoride. Later, therapeutic agents were included. Today's toothpastes have two objectives: to help the toothbrush in cleaning the tooth surface and to provide a therapeutic effect. The therapeutic effect may have an antiplaque or anti-inflammatory basis when the nature of the agents is antimicrobial. Plaque inhibitory and antiplaque activity of toothpastes used for chemical plaque control is evaluated in distinct consecutive stages, the last being home use randomized clinical trials of at least 6 months' duration. In this chapter, the scientific evidence supporting the use of the most common antiplaque agents, included in toothpaste formulations, is reviewed, with a special emphasis on 6-month clinical trials, and systematic reviews with meta-analyses of the mentioned studies. Among the active agents, the following have been included in toothpastes: enzymes, amine alcohols, herbal or natural products, triclosan, bisbiguanides (chlorhexidine), quaternary ammonium compounds (cetylpyridinium chloride) and different metal salts (zinc salts, stannous fluoride, stannous fluoride with amine fluoride). Dentifrices are the ideal vehicles for any active ingredient used as an oral health preventive measure since they are used in combination with toothbrushing, which is the most frequently employed oral hygiene method. The most important indications of dentifrices with active ingredients are associated with long-term use to prevent bacterial biofilm formation, mostly in gingivitis patients or in patients on supportive periodontal therapy.

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A randomised clinical trial to assess maintenance of gingival health by a novel gel to foam dentifrice containing 0.1%w/w o-cymen-5-ol, 0.6%w/w zinc chloride

Cited by 13 publications

References 5 publications

Preliminary Antiplaque Efficacy of <i>Aloe Vera</i> Mouthwash on 4 Day Plaque Re -Growth Model: Randomized Control Trial

Preliminary Antiplaque Efficacy of <i>Aloe Vera</i> Mouthwash on 4 Day Plaque Re -Growth Model: Randomized Control Trial

Maintenance of gingival health – a measure based on clinical indices

Antiplaque and Antigingivitis Toothpastes

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