A randomised, multicentre study of ceftriaxone versus standard therapy in the treatment of lower respiratory tract infections

Klerk, G.J. de; Steijn, J. H. M. Van; Lobatto, S.; Jaspers, C. A. J. J.; Veldhuizen, W.C.J. van; Hensing, C.A.J.; Bunnik, M.C.M.; Geraedts, Wiel; Dofferhof, Anthonius; Berg, Jw. van den; Melis, Joost; Hoepelman, Andy I. M.

doi:10.1016/s0924-8579(99)00037-0

Cited by 18 publications

(25 citation statements)

References 14 publications

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“…This is in line with previous studies; male gender is a risk factor for developing severe pneumonia with higher mortality. [3] [11,12] a fact that might have influenced antibiotic choice in CAP treatment by clinicians at WH.…”

Section: Discussion Determinants and Treatment Outcomesmentioning

confidence: 99%

Determinants, outcomes and costs of ceftriaxone v. amoxicillin-clavulanate in the treatment of community-acquired pneumonia at Witbank Hospital

2014

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Background. Community-acquired pneumonia (CAP) is a major cause of death and morbidity worldwide. Treatment is centred on antibiotics with ceftriaxone and amoxicillin-clavulanate being some of the most commonly prescribed agents. Objective. To compare treatment outcomes and costs in patients receiving either of these two antibiotics at Witbank Hospital (WH). Methods. A total of 200 randomly selected adult patient files (100 receiving ceftriaxone and 100 amoxicillin-clavulanate) recording a diagnosis of CAP were studied to determine the length of hospital stay, comorbid conditions and treatment outcomes. A descriptive and comparable analysis was performed. Results. Male gender, higher CURB-65 scores and death were associated with the use of ceftriaxone. Severity of disease and previous antibiotic exposure influenced the duration of hospital admission. Conclusion. Gender and severity of disease (based on the CURB-65 score) were the determinants of antibiotic choice at WH. Male gender increased the likelihood of being treated with ceftriaxone, as did a CURB-65 score of >2. There were no differences in the outcomes of CAP patients treated with ceftriaxone compared with those treated with amoxicillin-clavulanate. Irrespective of antibiotic used, gender and severity of disease influenced treatment outcomes. Male gender was associated with a higher mortality and longer hospital stay. The average duration of stay for both antibiotics was not significantly different. Thus, only level 1 and 2 costs need to be considered when comparing the two regimens. On this basis, ceftriaxone was cheaper than amoxicillin-clavulanate.

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Section: Discussion Determinants and Treatment Outcomesmentioning

confidence: 99%

Determinants, outcomes and costs of ceftriaxone v. amoxicillin-clavulanate in the treatment of community-acquired pneumonia at Witbank Hospital

2014

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“…Perhaps overlooked and most important, independent of health care cost, the charges to the patient are inseparably linked to dosing schedule. This impact of decreased dosing on antibiotic expenses has been emphasized by several authors [6][7][8][9][10][11]. In particular, a dramatic decrease in expense has been shown with once daily dosing of ceftriaxone compared to broad-spectrum monotherapeutic agents in the penicillin and cephalosporin families in several studies [6,[9][10][11][12][13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Single daily dosing ceftriaxone and metronidazole vs standard triple antibiotic regimen for perforated appendicitis in children: a prospective randomized trial

Peter

Tsao

Spilde

et al. 2008

Journal of Pediatric Surgery

129

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Introduction-Appendicitis is the most common emergency condition in children. Historically, a 3-drug regimen consisting of ampicillin, gentamicin, and clindamycin (AGC) has been used postoperatively for perforated appendicitis. A retrospective review at our institution has found single day dosing of ceftriaxone and metronidazole (CM) to be a more simple and cost-effective antibiotic strategy. Therefore, we performed a prospective, randomized trial to compare efficacy and cost-effectiveness of these 2 regimens.

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“…The regimen proposed herein maintains a favorable expense because of the infrequent dosing. The impact of decreased dosing on antibiotic expenses is a well-known phenomenon that has previously been addressed by several authors [8,[17][18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

“…In particular, a dramatic decrease in expense has been shown with once-daily dosing of ceftriaxone compared with broad-spectrum monotherapeutic agents in the penicillin and cephalosporin families in a multitude of studies [8][9][10][11][19][20][21][22][23]. There are no published data regarding propensity of microbial resistance between these 2 regimens.…”

Section: Discussionmentioning

confidence: 99%

A simple and more cost-effective antibiotic regimen for perforated appendicitis

Peter

Little

Calkins

et al. 2006

Journal of Pediatric Surgery

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A randomised, multicentre study of ceftriaxone versus standard therapy in the treatment of lower respiratory tract infections

Cited by 18 publications

References 14 publications

Determinants, outcomes and costs of ceftriaxone v. amoxicillin-clavulanate in the treatment of community-acquired pneumonia at Witbank Hospital

Determinants, outcomes and costs of ceftriaxone v. amoxicillin-clavulanate in the treatment of community-acquired pneumonia at Witbank Hospital

Single daily dosing ceftriaxone and metronidazole vs standard triple antibiotic regimen for perforated appendicitis in children: a prospective randomized trial

A simple and more cost-effective antibiotic regimen for perforated appendicitis

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