A randomised, prospective study of the effects of 3% diquafosol on ocular surface following cataract surgery

Abstract

There is still no established therapeutic solution for postoperative Dry Eye Syndrome (DES) after cataract surgery, in spite of progress in surgical techniques. Diquafosol tetrasodium (DQS), a recently developed ophthalmic solution, has been reported to be effective in DES, but no study evaluated post-cataract surgery lipid layer thickness (LLT) changes in healthy patients who used DQS postoperatively. We randomly divided participants into two groups; the DQS group was treated six times daily with DQS after cataract surgery, and the sodium hyaluronate (HA) group was treated with HA in the same way. Throughout study period, the DQS group showed significantly higher tear break up time (TBUT) and LLT than HA group. In multivariate analysis, better preoperative TBUT, Schirmer’s I test score, ocular surface disease index (OSDI) score, and LLT were significantly associated with improved postoperative outcomes in each parameter. Also, the postoperative use of DQS served as an independent parameter of better TBUT, OSDI score, and LLT in postoperative 15 weeks. Treatment with 3% DQS following cataract surgery showed more improvement in TBUT and LLT, compared with 0.1% HA. Improving TBUT and LLT preoperatively and using 3% DQS postoperatively, could be a reliable choice for managing DES after cataract surgery.Trial Registration: ISRCTN registry with ISRCTN 18755487.

Clinical Efficacy of an Eyedrop Containing Hyaluronic Acid and Ginkgo Biloba in the Management of Dry Eye Disease Induced by Cataract Surgery

“…It is possible that similar results in our study could be obtained also with other lubricating eyedrops. HA alone is in fact effective in reducing epithelial damage and improving TBUT after cataract surgery, 16 and we previously showed a beneficial effect after cataract surgery also using a combination of hypromellose and coenzyme Q10 17 and a combination of liposomes, omega 3, vitamin D and vitamin A palmitate 18 ; also diquafosol 19 ; and lifitegrast 20 ; showed beneficial effects.…”

Safety and efficacy of topical diquafosol for the treatment of dry eye disease: An updated meta-analysis of randomized controlled trials

“…Of them, 52 full text papers were examined for eligibility. Fourteen RCTs[ 15 - 17 , 30 - 40 ] were eventually included in our systematic review and meta-analysis.…”

Evaluation of Ocular Surface after Cataract Surgery—A Prospective Study

“…Our results show that dry eye symptoms and ocular surface dysfunction signs are quite common before the cataract surgery, and they only worsen after phacoemulsification. There are a few studies that evaluated medications for dry eye symptoms and signs occurring after the phacoemulsification: trehalose/sodium hyaluronate [ 46 ], trehalose/hyaluronic acid vs. hyaluronic acid [ 47 ], 3% diquafosol [ 48 ], and 0.05% cyclosporine A [ 49 ] which all had positive outcomes.…”