“A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma” of Yoko Harima et al. (2001): multiple biases and no advantage of hyperthermia

Roussakow, Sergey

doi:10.1080/02656736.2018.1447696

Cited by 5 publications

(2 citation statements)

References 4 publications

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“…Its combination with chemotherapy (Cisplatin + hyperthermia for previously radiated cases) also shows feasibility ( 182 , 183 ), as well as the combination with radiation ( 184 – 186 ) showing great success. However new evidence ( 176 ) fueled the debate with counterpoints ( 187 ), counterarguments ( 188 , 189 ), further debates ( 190 ), and responses thereto ( 191 ). Some further bimodal ( 192 , 193 ) and trimodal applications for the cervix ( 194 – 196 ) were also reported regarding locally advanced disease.…”

Section: Effects Of Hyperthermiamentioning

confidence: 99%

Quo Vadis Oncological Hyperthermia (2020)?

et al. 2020

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Heating as a medical intervention in cancer treatment is an ancient approach, but effective deep heating techniques are lacking in modern practice. The use of electromagnetic interactions has enabled the development of more reliable localregional hyperthermia (LRHT) techniques whole-body hyperthermia (WBH) techniques. Contrary to the relatively simple physical-physiological concepts behind hyperthermia, its development was not steady, and it has gone through periods of failures and renewals with mixed views on the benefits of heating seen in the medical community over the decades. In this review we study in detail the various techniques currently available and describe challenges and trends of oncological hyperthermia from a new perspective. Our aim is to describe what we believe to be a new and effective approach to oncologic hyperthermia, and a change in the paradigm of dosing. Physiological limits restrict the application of WBH which has moved toward the mild temperature range, targeting immune support. LRHT does not have a temperature limit in the tumor (which can be burned out in extreme conditions) but a trend has started toward milder temperatures with immune-oriented goals, developing toward immune modulation, and especially toward tumor-specific immune reactions by which LRHT seeks to target the malignancy systemically. The emerging research of bystander and abscopal effects, in both laboratory investigations and clinical applications, has been intensified. Our present review summarizes the methods and results, and discusses the trends of hyperthermia in oncology.

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Section: Effects Of Hyperthermiamentioning

confidence: 99%

Quo Vadis Oncological Hyperthermia (2020)?

et al. 2020

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“…A further study of cervix carcinomas supports the survival benefit [ 83 ], but again a critic has questioned this result [ 84 , 85 ]. Another phase III trial of cervical carcinomas with HT plus brachytherapy involving 224 patients noticed the same controversies between survival time and local control [ 86 ].…”

Section: Introductionmentioning

confidence: 99%

Heterogeneous Heat Absorption Is Complementary to Radiotherapy

Szász

2022

Cancers

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(1) Background: Hyperthermia in oncology conventionally seeks the homogeneous heating of the tumor mass. The expected isothermal condition is the basis of the dose calculation in clinical practice. My objective is to study and apply a heterogenic temperature pattern during the heating process and show how it supports radiotherapy. (2) Methods: The targeted tissue’s natural electric and thermal heterogeneity is used for the selective heating of the cancer cells. The amplitude-modulated radiofrequency current focuses the energy absorption on the membrane rafts of the malignant cells. The energy partly “nonthermally” excites and partly heats the absorbing protein complexes. (3) Results: The excitation of the transmembrane proteins induces an extrinsic caspase-dependent apoptotic pathway, while the heat stress promotes the intrinsic caspase-dependent and independent apoptotic signals generated by mitochondria. The molecular changes synergize the method with radiotherapy and promote the abscopal effect. The mild average temperature (39–41 °C) intensifies the blood flow for promoting oxygenation in combination with radiotherapy. The preclinical experiences verify, and the clinical studies validate the method. (4) Conclusions: The heterogenic, molecular targeting has similarities with DNA strand-breaking in radiotherapy. The controlled energy absorption allows using a similar energy dose to radiotherapy (J/kg). The two therapies are synergistically combined.

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Nanomaterials for Biomedical Engineering Applications

Singh

Patel

2022

Nanomaterials for Advanced Technologies

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“A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma” of Yoko Harima et al. (2001): multiple biases and no advantage of hyperthermia

Cited by 5 publications

References 4 publications

Quo Vadis Oncological Hyperthermia (2020)?

Quo Vadis Oncological Hyperthermia (2020)?

Heterogeneous Heat Absorption Is Complementary to Radiotherapy

Nanomaterials for Biomedical Engineering Applications

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