A Randomized Comparative Clinical Trial of Swarnmakshika Bhasma and Compound (Swarnmakshika Bhasma and Yashada Bhasma) in the Management of Pandu With Special Reference to Iron Deficiency Anemia

Abstract

Iron deficiency anemia (IDA) is most prevalent nutritional deficiency worldwide. Anemia generally manifests as easy fatigability, exertional dyspnoea, palpitations, body aches and giddiness depending upon its severity, rapidity of onset and underlying pathology. Treatment of iron deficiency anemia mainly involves correction by iron supplementation but constipation, diarrhea, nausea, epigastric discomfort etc. are frequently encountered as side effects during clinical practice. Pandu has been described in Ayurvedic texts under which all types and causes of anemias can be incorporated. Pitta and rakta are considered main vitiated entities in Pandu. Swarnmakshika and Yashada bhasmas are described to have pandu roga shamak (drugs mitigating anemia) properties hence were selected for the study. Total 30 patients were registered for the trial, 28 completed the trial who were randomly distributed in two groups. Group-I was given Swarnmakshika bhasma and Group-II was given the compound bhasma (Swarnmakshika bhasma + Yashada bhasma) to compare the efficacy of both the formulations. Results were statistically significant in both the trial groups but objective parameters showed better results in trial group-II. Hence it can be concluded that both the formulations have definite hematinic effect but addition of Yashada bhasma with Swarnmakshika bhasma increases its efficacy.

Efficacy of majun e khabsul hadeed in iron deficiency anemia in reproductive age group: A randomised control study

“…It is very much consistent with the results of previous studies conducted by Nagesh CS et al, Meghna V, Abhishek. [28][29][30] The objective parameters viz. Hb%, PCV, MCV, MCH, MCHC, RBC count were also significantly improved after treatment with p<0.001 in both groups.On intergroup comparison p >0.05 showed that there was no statistically significant difference between the two groups suggesting that test drug is as effective as control drug inthe improvement of objective parameters.These results are comparable with the studies conducted by Vaidya Meghna et al 29 Pharmacopeial formulation, "Majunekhabsulhadeed" a jelly form medicinecontains amla khusk, balchar, baheda, peepalkalan, tukhmeshibt, tukhmgandana, zanjabeel, chitalakri, saad kufi, filfilsiyah, halelasiyah, ghee and khabsulhadeed mudabbar.…”

“…[28][29][30] The objective parameters viz. Hb%, PCV, MCV, MCH, MCHC, RBC count were also significantly improved after treatment with p<0.001 in both groups.On intergroup comparison p >0.05 showed that there was no statistically significant difference between the two groups suggesting that test drug is as effective as control drug inthe improvement of objective parameters.These results are comparable with the studies conducted by Vaidya Meghna et al 29 Pharmacopeial formulation, "Majunekhabsulhadeed" a jelly form medicinecontains amla khusk, balchar, baheda, peepalkalan, tukhmeshibt, tukhmgandana, zanjabeel, chitalakri, saad kufi, filfilsiyah, halelasiyah, ghee and khabsulhadeed mudabbar. 31 The improvement in the subjective and objective parameters seen in the present study as iron oxide per se provides blood iron (Fe) and act as an antioxidant compound, in addition to the supplementary effect of the chemical constituents of the ingredients of majunekhabsulhadeedviz.…”