A randomized comparative evaluation of clinical and home application to investigate the effectiveness of silver nitrate (AgNO3) (95%) for the treatment of verruca pedis

Concannon, Michael; Keogh, Lisa; Stephenson, John; Parfitt, Grace; Forrest, J M

doi:10.1111/ijpp.12345

Cited by 6 publications

(5 citation statements)

References 22 publications

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“…Silver nitrate: Children and adults with hand and foot warts received therapy with a 10% solution of silver nitrate, and after six weeks, 63% of patients had cleared up [31] .…”

Section: Chemicalmentioning

confidence: 99%

Different modalities in the treatment of verruca

Amawy,

Hassan,

Maghraby

et al. 2023

Int. J. Dermatol. Venereology Leprosy Sci.

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Verruca (wart) is a common proliferation of skin and mucosa duo to human papillomaviruses (HPV) infection. They might be as little as a few millimetres or as large as several centimetres. They might be skin-colored or brownish-gray in hue. There is no need for further histologic or virologic tests because the diagnosis has been made clinically. There isn't a particular antiviral treatment for HPV available right now, however, some medications on the market disrupt the viral life cycle. There are several wart therapies accessible, however there can often be inadequate backing for their benefit, whether they are taken alone or in combination. Damage to the infected epithelium that ends up in cell death, antigen exposure, presentation, and an immune response is the most conventional kind of therapy. The wart should thin out as a result of diminishing epidermal proliferation, or more particularly DNA replication, which additionally ought to prevent the propagation of new viruses. Although there is currently no entirely appropriate course of treatment that would ensure complete cure, without relapses, wart treatment is still exceedingly difficult in contemporary dermatology. The majority of treatment methods involve numerous uncomfortable procedures rather than concentrating on eliminating the viral agent that is the cause of the illness. The main justification for the continued use of traditional medical practises and cures is this. The part doctors play in the healing process is being reevaluated. Any medical practise should be built on a partnership between the doctor and the patient, where accountability is shared and decisions are made together.

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“…Silver nitrate: Children and adults with hand and foot warts received therapy with a 10% solution of silver nitrate, and after six weeks, 63% of patients had cleared up [31] .…”

Section: Chemicalmentioning

confidence: 99%

Different modalities in the treatment of verruca

Amawy,

Hassan,

Maghraby

et al. 2023

Int. J. Dermatol. Venereology Leprosy Sci.

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“…9 A recent RCT investigating weekly applications of 95% silver nitrate for the treatment of Verruca pedis in adults found complete response in 37.5% of participants after 10 weeks. 10 In a placebocontrolled randomised trial of 10% silver nitrate solution applied alternate daily for three weeks, complete regression of palmar and plantar lesions was achieved in 63% of adults and children. Participants experienced a mild-to-moderate burning sensation, itching and temporary discolouration of the skin.…”

Section: Silver Nitratementioning

confidence: 99%

Destructive therapies for cutaneous warts: A review of the evidence

Truong¹,

Manago²,

Joseph

et al. 2022

Aust J Gen Pract

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COMMON WARTS (Verruca vulgaris), plantar warts (Verruca plantaris) and flat/plane warts (Verruca plana), collectively known as cutaneous warts, are benign growths of the skin caused by the human papillomavirus (HPV). In Australia, up to 24% of children and 5% of adults are affected. 1 A break in the epidermal barrier of the skin allows entry of HPV and subsequent infection of basal epithelial cells. HPV replicates alongside the natural lifecycle of epithelial cells, and is eventually released from desquamated keratinocytes on the surface of warts, potentially infecting other sites via direct contact or through fomites. 2 Cutaneous warts generally self-resolve. Up to two-thirds of immunocompetent children experience spontaneous clearance of their cutaneous warts by two years of age. 3 Adults tend to take longer. Patients might request treatment for their warts when they cause discomfort, functional impairment, social ostracism, are numerous, grow large or raise concerns regarding transmission. 4 Treatment for cutaneous warts can be painful, scar, cause pigmentary disturbances and might not be effective. 5 Therefore, clinicians should be wary of the evidence behind the efficacy of cutaneous wart treatment. This review summarises high-quality studies investigating the efficacy of chemical and physical destructive wart therapies. MethodsWe performed a literature review (up to June 2021) of published articles for wart management from the MEDLINE and Embase databases. No language restrictions were applied. We considered systematic reviews, randomised controlled trials (RCTs), cohort studies and case series. Case reports were excluded. For MEDLINE, we used the Boolean operation to combine MeSH terms 'warts' AND 'therapeutics'. For Embase, we used the Boolean operation to combine MeSH terms 'Verruca vulgaris' AND 'therapy'. We included studies that investigated chemical or physical destructive therapies.

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“…[121][122][123][124][125][126] Inorganic nitrate has been used for the treatment of human papilloma virus. 127 Phase II clinical trials have found that acidified nitrite in cream reduced Leishmania major/ tropica amastigotes and promastigotes with a reduction in cutaneous leishmaniasis 123 and increased cure rates in tinea pedis. 121 Novel NO agents are in development to treat skin conditions (Table 8).…”

Section: Cutaneous Infectionsmentioning

confidence: 99%

Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections

et al. 2021

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Although the antimicrobial potential of nitric oxide (NO) is widely published, it is little used clinically. NO is a key signalling molecule modulating vascular, neuronal, inflammatory and immune responses. Endogenous antimicrobial activity is largely mediated by high local NO concentrations produced by cellular inducible nitric oxide synthase, and by derivative reactive nitrogen oxide species including peroxynitrite and S-nitrosothiols. NO may be taken as dietary substrate (inorganic nitrate, L-arginine), and therapeutically as gaseous NO, and transdermal, sublingual, oral, intranasal and intravenous nitrite or nitrate. Numerous preclinical studies have demonstrated that NO has generic static and cidal activities against viruses (including β-coronaviruses such as SARS-CoV-2), bacteria, protozoa and fungi/yeasts in vitro. Therapeutic effects have been seen in animal models in vivo, and phase II trials have demonstrated that NO donors can reduce microbial infection. Nevertheless, excess NO, as occurs in septic shock, is associated with increased morbidity and mortality. In view of the dose-dependent positive and negative effects of NO, safety and efficacy trials of NO and its donors are needed for assessing their role in the prevention and treatment of infections. Trials should test dietary inorganic nitrate for pre- or post-exposure prophylaxis and gaseous NO or oral, topical or intravenous nitrite and nitrate for treatment of mild-to-severe infections, including due to SARS-CoV-2 (COVID-19). This review summarises the evidence base from in vitro, in vivo and early phase clinical studies of NO activity in viral, bacterial, protozoal and fungal infections.

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A randomized comparative evaluation of clinical and home application to investigate the effectiveness of silver nitrate (AgNO3) (95%) for the treatment of verruca pedis

Cited by 6 publications

References 22 publications

Different modalities in the treatment of verruca

Different modalities in the treatment of verruca

Destructive therapies for cutaneous warts: A review of the evidence

Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections

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