A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes

Thaipitakwong, Thanchanit; Supasyndh, Ouppatham; Rasmi, Yousef; Aramwit, Pornanong

doi:10.1016/j.ctim.2019.102292

Cited by 53 publications

(38 citation statements)

References 32 publications

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“…Of the 10 studies, three [ 20 , 22 , 26 ] were conducted in Korea, two each in United States [ 21 , 27 ] and Japan [ 23 , 25 ], and one each in UK [ 28 ], China [ 29 ], and Thailand [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…IGT refers to FBS levels from 100 mg/dL to 125 mg/dL. Two studies [ 23 , 24 ] recruited individuals with FBS of 100–140 mg/dL. In 13 RCTs, five trials included healthy people, six included individuals with hyperglycemia, and one used both.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, for more accurate results, analyses in four trials were conducted with a wash-out period. However, the RCT by Thaipitakwong included only one test [ 24 ]; however, it had three dose groups. Several long-term studies had a run-in period and follow-up period.…”

Section: Resultsmentioning

confidence: 99%

“…No treatment was performed in four trials. However, in Thaipitakwong's long-term study [ 24 ], diet education was conducted for comparison with the treatment group.…”

Section: Resultsmentioning

confidence: 99%

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Morus alba L. for Blood Sugar Management: A Systematic Review and Meta-Analysis

Jeong

Jang

Kim

2022

Evidence-Based Complementary and Alternative Medicine

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Introduction. Morus alba L. is used for blood sugar management in patients with diabetes mellitus. This review aimed to evaluate the effect of Morus alba on blood sugar management. Methods. This review was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). We searched PubMed, EMBASE, and four Korean medical databases (RISS, OASIS, NDSL, and KISS) using relevant keywords. Randomized controlled trials with any type of control intervention were included. The selection of studies, data extraction, and quality assessment were performed independently by two researchers. Results. Our results showed that Morus alba can reduce postprandial glucose and insulin levels. However, it is insufficient to conclude that Morus alba is an effective intervention for lowering blood glucose levels. Therefore, more rigorous studies are needed to reveal the effect of MA on blood glucose levels. Conclusion. The conclusion of this review provides evidence that Morus alba can control blood sugar level. This systematic review was registered with the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42021255940).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…No treatment was performed in four trials. However, in Thaipitakwong's long-term study [ 24 ], diet education was conducted for comparison with the treatment group.…”

Section: Resultsmentioning

confidence: 99%

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Morus alba L. for Blood Sugar Management: A Systematic Review and Meta-Analysis

Jeong

Jang

Kim

2022

Evidence-Based Complementary and Alternative Medicine

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“…Hypoglycemic (Thaipitakwong, Supasyndh, Rasmi, & Aramwit, 2020)…”

Section: Introductionmentioning

confidence: 99%

Advances in understanding of health‐promoting benefits of medicine and food homology using analysis of gut microbiota and metabolomics

et al. 2020

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The health-promoting benefits of medicine and food homology (MFH) are known for thousands of years in China. However, active compounds and biological mechanisms are unclear, greatly limiting clinical practice of MFH. The advent of gut microbiota analysis and metabolomics emerge as key tools to discover functional compounds, therapeutic targets, and mechanisms of benefits of MFH. Such studies hold great promise to promote and optimize functional efficacy and development of MFH-based products, for example, foods for daily dietary supplements or for special medical purposes. In this review, we summarized pharmacological effects of 109 species of MFH approved by the Health and Fitness Commission in 2015. Recent studies applying genome sequencing of gut microbiota and metabolomics to explain the activity of MFH in prevention and management of health consequences were extensively reviewed. We discussed the potentiality in future to decipher functional activities of MFH by applying metabolomics-based polypharmacokinetic strategy and multiomics technologies. The needs for personalized MFH recommendations and comprehensive databases have also been highlighted. This review emphasizes current achievements and challenges of the analysis of gut microbiota and metabolomics as a new avenue to understand MFH. K E Y W O R D S gut microbiota, medicine and food homology, metabolomics, multiomics technology Abbreviations: IBD, inflammatory bowel disease; LPS, lipopolysaccharide; MFH, medicine and food homology; SCFA, short-chain fatty acid; TCMIO, a comprehensive database of traditional Chinese medicine on immuno-oncology; WEGL, water extract of Ganoderma lucidum mycelium This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Non‐silk Applications of Mulberry Plants

2021

Sustainable Use of Byproducts From Silk Processing

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A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes

Cited by 53 publications

References 32 publications

Morus alba L. for Blood Sugar Management: A Systematic Review and Meta-Analysis

Morus alba L. for Blood Sugar Management: A Systematic Review and Meta-Analysis

Advances in understanding of health‐promoting benefits of medicine and food homology using analysis of gut microbiota and metabolomics

Non‐silk Applications of Mulberry Plants

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