A randomized, controlled study of oral gentamicin in the treatment of neonatal necrotizing enterocolitis

Anaerobic Antimicrobial Therapy After Necrotizing Enterocolitis in VLBW Infants

“…The overall mortality we observed (26%) is consistent with previous data from cohorts combining infants with medical and surgical NEC (15%-25%), 20,21,25 but the incidence of intestinal strictures is in the lower range reported in the literature (3% vs 4%-30%). 4,20,21,[26][27][28][29][30] The wide range of stricture incidence reported is probably a result of inconsistent definitions leading to ascertainment bias; some studies might report all strictures as diagnosed with radiologic tests, whereas others might report only symptomatic strictures.…”

“…4,20,21,[26][27][28][29][30] The wide range of stricture incidence reported is probably a result of inconsistent definitions leading to ascertainment bias; some studies might report all strictures as diagnosed with radiologic tests, whereas others might report only symptomatic strictures. The diagnosis of stricture in our data is limited to those reported by the treating physician in the electronic medical record.…”

“…Despite this finding, clindamycin is often used for NEC in the nursery, and the safety and efficacy of other antibiotic regimens for NEC have not been established. [20][21][22] The objective of the current study was to assess the association of anaerobic antimicrobial therapy and subsequent clinical outcomes in very low birth weight (VLBW, #1500 g BW) infants.…”

Neonatal Necrotising Enterocolitis

“…The addition of clindamycin to am picillin and gentamicin for the treatment of NEC does not reduce the frequency of intes tinal gangrene or bowel perforation [71], Oral gentamicin, added to parenteral thera py, has been shown to have no effect on the course of the disease [72], Abdominal X-rays should be performed regularly during the acute period to monitor for perforation [4], Kosloske et al [73] sug gest that the presence of portal venous gas and/or severe pneumatosis intestinalis is fre quently associated with pan-necrosis and a poor prognosis. Intestinal perforation occurs in up to 30% of cases and generally requires surgical intervention [74], Abdominal para centesis may aid in the diagnosis of intesti nal gangrene and perforation [75].…”

Gentamicin Absorption during Prophylactic Use for Necrotizing Enterocolitis

“…There have also been publications suggesting absorption of enterally admin istered aminoglycosides, especially when mucosal integrity is breached dur ing necrotizing enterocolitis (NEC) [3,4,6,8].…”