A randomized controlled trial of the efficacy of two weeks of omeprazole and clarithromycin vs. one week of omeprazole, clarithromicin and amoxicillin for cure of Helicobacter pylori infection in primary care: Preliminary results

Calvet, Xavier; Medicina, Servei de; Taulí, Consorci Hospitalari del Parc; Cubells, M. L.; Lorente, T López; Baré, Marisa; Gálvez, Eva; Molina, E; Estève,

doi:10.1016/s0016-5085(98)80334-x

Cited by 1 publication

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“…Forty‐seven studies of 1‐week triple therapy with omeprazole, clarithromycin and amoxycillin (OCA) were identified, from which the ITT eradication rate could be determined 14 , . 17 , 19 , 20 , 23 –65 It was unavailable from another 19 studies 66 –84 …”

Section: Resultsmentioning

confidence: 99%

“…+ A 1 g b.d 14 , . 19 , 20 , 25 , 26 , 28 , 29 , 34 , 35 , 38 , 41 , 42 , 44 –50 , 52 , 56 , 57 , 59 , 62 , 64 giving a pooled eradication rate of 82.3% ( n = 1439/1749); range 61–95% 19 , . 29 Studies have been carried out with the same doses of O + A with C 250 mg b.d 24 , .…”

Section: Resultsmentioning

confidence: 99%

“…Twice daily O 20 mg has been studied most frequently 14 , 19 , 20 , 24 –32 , 34 , 35 , 37 –39 , 41 –50 , 52 , 53 , 56 –62 , 64 , 65 with a pooled eradication rate of 82.3% ( n = 2364/2871). In two studies, 33 , 55 O 40 mg b.d.…”

Section: Resultsmentioning

confidence: 99%

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One‐week clarithromycin triple therapy regimens for eradication of Helicobacter pylori

Pipkin

Williamson

Wood

1998

Aliment Pharmacol Ther

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Background: One‐week triple therapies have been endorsed as the treatment regimens of choice for eradication of Helicobacter pylori infection. Those that include clarithromycin appear to be the most effective. Aim: To review reports of triple therapies that include clarithromycin. Methods: Reports were identified from the literature to May 1998. The variation between study designs prevents a formal meta‐analysis. A measure of the relative efficacies of regimens has, however, been gained by comparison and by pooling of intention‐to‐treat eradication rates. Results: One hundred and ninety‐two studies were identified which included 264 treatment arms of a 1‐week triple therapy composed of clarithromycin with amoxycillin or a nitroimidazole (metronidazole or tinidazole), and either ranitidine bismuth citrate or a proton pump inhibitor (omeprazole, lansoprazole or pantoprazole). From reports of these studies, an intention‐to‐treat H. pylori eradication rate could be determined from 210 treatment arms of 151 studies. Conclusions: There is little to choose between the efficacies of 1‐week clarithromycin‐based triple therapy eradication regimens. However, those comprising clarithromycin, a nitroimidazole and either ranitidine bismuth citrate or a high dose of omeprazole are, in general, the most effective. Against antibiotic‐resistant strains of H. pylori, regimens including ranitidine bismuth citrate may be more effective than those including a proton pump inhibitor.

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