A Randomized, Controlled, Trial of Controlled Release Paroxetine in Fibromyalgia

Patkar, Ashwin A.; Masand, Prakash S.; Krulewicz, Stan; Mannelli, Paolo; Peindl, Kathleen; Beebe, Katherine; Jiang, Wei

doi:10.1016/j.amjmed.2006.06.006

Cited by 80 publications

(74 citation statements)

References 30 publications

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“…50,54,56,[97][98][99][100][101][102] Five studies comparing SSRIs with placebo have found them to be superior to placebo for relieving neuropathic pain. 50,[103][104][105][106] In fibromyalgia, fluoxetine (ES: 1.08) is reported to have greater analgesic activity than citalopram (ES: 0.45) and paroxetine (ES: 0.19).…”

Section: Selective Serotonin Reuptake Inhibitorsmentioning

confidence: 99%

Efficacy of Antidepressants as Analgesics: A Review

Dharmshaktu¹,

Tayal²,

Kalra³

2012

The Journal of Clinical Pharma

279

189

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Persistent pain disorders are usually not adequately alleviated by nonsteroidal anti‐inflammatory drugs or other simple analgesics. Use of antidepressants as adjuvant therapy for the control of persistent pain is currently being practiced in disorders such as fibromyalgia, neuropathic pain, rheumatoid conditions, low back pain, and headache. This review describes the various mechanisms of analgesic activity of antidepressants along with their efficacy and tolerability profiles. Meta‐analyses and clinical studies of these agents were retrieved through the use of MEDLINE, Google scholar, and Cochrane databases. Antidepressants are effective in both neuropathic and non‐neuropathic pain and have diverse mechanisms independent of their antidepressant effects. Tricyclic antidepressants (amitryptiline, nortryptiline, desipramine) are effective compounds in the treatment of neuropathic pain, fibromyalgia, low back pain, and headaches. Studies are ongoing for the dual serotonin norepinephrine reuptake inhibitors (duloxetine, venlafaxine) in several persistent pain conditions and these may be recommended in neuropathic pain, migraines, and fibromyalgia. Evidence suggests that although the analgesic effects of selective serotonin reuptake inhibitors (fluoxetine, paroxetine, citalopram) are limited and inconsistent, yet they have a superior tolerability profile compared with tricyclic antidepressants.

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Section: Selective Serotonin Reuptake Inhibitorsmentioning

confidence: 99%

Efficacy of Antidepressants as Analgesics: A Review

Dharmshaktu¹,

Tayal²,

Kalra³

2012

The Journal of Clinical Pharma

279

189

View full text Add to dashboard Cite

show abstract

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids are probably not effective in the treatment of fibromyalgia, despite their routine use. Benzo-PSYCHIATRIST.COM fibromyalgia either as monotherapy 82,83 or in combination with TCAs. 40 Fluoxetine monotherapy 84 and cyclobenzaprine monotherapy 85 have been efficacious for certain outcome measures in fibromyalgia, but the combination of fluoxetine and cyclobenzaprine demonstrated the most effective results.…”

Section: Pharmacotherapy For Patients With Fibromyalgiamentioning

confidence: 99%

Understanding Fibromyalgia and Its Related Disorders

Goldenberg¹

2008

Prim. Care Companion J. Clin. Psychiatry

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“…These drugs act by engaging high-voltage activated Ca 2+ channels and the K v 1 family of K + channels as well as by modifying defective serotonergic circuitry exemplified by abnormalities in serotonergic receptor-related events which appear to be the basis for therapy of FMS with serotonin-specific reuptake inhibitors (SSRIs) such as paroxetine [34]. Furthermore, implicating the serotonin-norepinephrine pathway as a relevant mechanism for pain modulation is likely the rationale why serotonin-norepinephrine reuptake inhibitors (SNRIs) have now been added to the pharmacotherapeutic armamentarium for FMS [35][36][37].…”

Section: Pregabalin Amitryptyline and Paraxotine Alter Neutrotransmimentioning

confidence: 99%

Regulation of Pain in Fibromyalgia by Selective Serotonin and Serotonin Norepinephrine Reuptake Inhibition

Malemud¹

2013

Int J Phys Med Rehabil

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A Randomized, Controlled, Trial of Controlled Release Paroxetine in Fibromyalgia

Cited by 80 publications

References 30 publications

Efficacy of Antidepressants as Analgesics: A Review

Efficacy of Antidepressants as Analgesics: A Review

Understanding Fibromyalgia and Its Related Disorders

Regulation of Pain in Fibromyalgia by Selective Serotonin and Serotonin Norepinephrine Reuptake Inhibition

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