A randomized, controlled trial of platelet transfusions in thrombocytopenic premature infants

Andrew, Maureen; Vegh, Patsy; Caco, Chris; Kirpalani, Haresh; Jefferies, Ann L; Ohlsson, Arne; Watts, John; Saigal, Saroj; Milner, Ruth; Wang, E.

doi:10.1016/s0022-3476(05)81705-6

Cited by 235 publications

(199 citation statements)

References 33 publications

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“…In this study, giving platelet transfusions to infants with a platelet count of less than 150 000 did shorten bleeding times but did not reduce the incidence or extent of IVH. 15 In our population of VLBW infants, those with IVH, severe IVH and severe IVH and/or death were more likely to have platelet mass <10th percentile in the first 2 days of life, but platelet mass did not differ on the day of birth. IVH in premature infants occurs within the first week of life, with the majority occurring within the first 4 days.…”

Section: Discussionmentioning

confidence: 66%

Is a small platelet mass associated with intraventricular hemorrhage in very low-birth-weight infants?

Mackley

Christensen

et al. 2011

J Perinatol

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Section: Discussionmentioning

confidence: 66%

Is a small platelet mass associated with intraventricular hemorrhage in very low-birth-weight infants?

Mackley

Christensen

et al. 2011

J Perinatol

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“…22 They are also recommended as prophylaxis against bleeding if the count falls sufficiently low. [23][24][25] Precisely how low to permit a platelet count to fall in an ELBW neonate before ordering a platelet transfusion is not known. We found that platelet transfusions were nearly always given for prophylaxis against bleeding rather than to treat active bleeding.…”

Section: Discussionmentioning

confidence: 99%

Thrombocytopenia among extremely low birth weight neonates: data from a multihospital healthcare system

Henry²,

et al. 2006

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Objectives: Thrombocytopenia is common in neonatal intensive care units (NICU), with 18 to 35% of patients developing this problem before hospital discharge. It might be even more common among extremely low birth weight neonates (ELBW, p1000 g birth weight). However, little is known about thrombocytopenia in the ELBW population. We sought to determine the incidence, timing, causes, platelet transfusions given, and outcomes of thrombocytopenia among ELBW neonates. Results: Multiple platelet counts were obtained in all 284 (range, 4 to 441 platelet counts/patient). Of the 284, 208 (73%) had one or more platelet counts p150 000/ml. Most were detected during the first days of life; 80% were detected during the first week and only 20% were detected thereafter. Thrombcytopenia was more common among the smallest patients; 85% incidence among those p800 g, 60% among those 801 to 900 g, and 53% among those 901 to 1000 g. Platelet transfusions were given to 129 of the 208 thrombocytopenic neonates. More than 90% were given prophylactically (the patient was not bleeding). The mortality rate among those that received platelet transfusions was twice that of those that received no platelet transfusions (P<0.01). In 48% of cases, the cause of the thrombocytopenia went undiagnosed. The most common explanations were being small for gestational age or delivered to a hypertensive mother, DIC, bacterial infection, fungal infection, and necrotizing enterocolitis, respectively. Conclusions:We observed thrombocytopenia among ELBW neonates at a rate more than twice that reported among the general NICU population. Much remains to be discovered about the etiology and best treatments of thrombocytopenia among ELBW neonates.

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“…52 neurological damage or death. [53][54][55][56] To correct an abnormal platelet count, the cause of the thrombocytopenia should be taken into account.…”

Section: Recombinant Erythropoietinmentioning

confidence: 99%

Neonatal Transfusion Practices

Sesok‐Pizzini¹

2017

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A randomized, controlled trial of platelet transfusions in thrombocytopenic premature infants

Cited by 235 publications

References 33 publications

Is a small platelet mass associated with intraventricular hemorrhage in very low-birth-weight infants?

Is a small platelet mass associated with intraventricular hemorrhage in very low-birth-weight infants?

Thrombocytopenia among extremely low birth weight neonates: data from a multihospital healthcare system

Neonatal Transfusion Practices

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