A Randomized Controlled Trial to Prevent Post-Operative Atrial Fibrillation by Antioxidant Reinforcement

Abstract

This safe, well-tolerated, and low-cost regimen, consisting of n-3 polyunsaturated fatty acids plus vitamins C and E supplementation, favorably affected post-operative atrial fibrillation, increased antioxidant potential, and attenuated oxidative stress and inflammation. (Prevention of Post-Operative Atrial Fibrillation: Pathophysiological Characterization of a Pharmacological Intervention Based on a Novel Model of Nonhypoxic Pre-Conditioning; ISRCTN45347268).

Vitamin C for the Prevention of Postoperative Atrial Fibrillation after Cardiac Surgery: A Meta-Analysis

“…3 studies were excluded, as they administered vitC combined with other treatments under evaluation. [24][25][26] 2 studies in clinical trial registries were excluded for not posting results, and authors were unavailable for comment. 27,28 1 study in a Russian language journal was excluded, as the journal was unavailable in electronic or print form, and the journal did not make its articles available outside the Russian Federation.…”

Atrial Fibrillation Initiated by Early Afterdepolarization-Mediated Triggered Activity during Acute Oxidative Stress: Efficacy of Late Sodium Current Blockade

“…It is quite difficult, if not impossible, to obtain reliable recordings of cellular events in intact human hearts at the onset of AF [33]. Human clinical studies demonstrated the occurrence of new onset acute oxidative AF by showing that inhalation of pro-oxidant particulate matters promotes acute AF in patients with cardiac disease [34] and that such effects can be minimized by antioxidant therapy [35]. Genomic analyses showed that genes that were uniquely up regulated in patients with no POAF were mostly supported by reduction reactions suggesting that the overall redox balance favors anti-oxidant state in these patients resistant to POAF [3].…”

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

“…Inne metody leczenia również oceniano w małych próbach klinicznych generujących nowe hipotezy badawcze, ale nie wykazano jednoznacznie ich korzystnych efektów. Do ocenianych metod należało stosowanie magnezu [925,935,936], wielonienasyconych kwasów tłuszczowych z grupy omega-3 [937][938][939][940][941][942][943][944][945], kolchicyny [946] i glikokortykosteroidów [947,948], a także wycięcie tylnej części osierdzia [949]. Pooperacyjna stymulacja dwuprzedsionkowa narzuconym szybkim rytmem (overdrive) nie znalazła powszechnego zastosowania mimo pewnych danych wskazujących na jej profilaktyczny efekt [925,950].…”