A randomized, controlled, two-month pilot trial of stannous fluoride dentifrice versus sodium fluoride dentifrice after oxalate treatment for dentinal hypersensitivity

Abstract

Objectives To compare the effects of a stannous fluoride dentifrice and a sodium fluoride dentifrice on dentinal hypersensitivity when used with an oxalate-based regimen combining in-office and at-home treatment. Materials and methods In this single-center, randomized, controlled, double-blind, pilot clinical trial, 30 subjects were professionally treated at baseline with a 3% oxalate/potassium salt solution on up to two target teeth, then randomized 1:1 to either 0.454% stannous fluoride or 0.243% sodium fluoride overlabeled dentifrice. Both groups were given 6 sensitivity strips (3.14% potassium oxalate gel) and a soft, manual toothbrush. Subjects were permitted to apply strips on up to two teeth, up to three times per tooth, at home as desired throughout the study. Dentinal sensitivity (cold air blast challenge) was assessed at baseline, immediately after post-professional treatment, and at day 60 using the Schiff scale and a Visual Analog Scale (VAS). Results Immediately after professional oxalate treatment, the overall mean Schiff and VAS score decreased 25.6% and 22.4% from baseline, respectively (p ≤ 0.001 for both). At day 60, further reductions in both mean scores were seen in both groups. There were no significant differences between the groups at day 60. All treatments were well tolerated. Conclusions In subjects treated with oxalates for dentinal hypersensitivity, both stannous fluoride and sodium fluoride dentifrices are well tolerated, are feasible for routine use, and do not detract from the desensitizing effects of an in-office and at-home oxalate combination treatment regimen. Clinical relevance Either stannous fluoride or sodium fluoride dentifrices can be recommended to dentinal hypersensitivity patients who undergo professional oxalate treatment.

Enhancing the inhibition of dental erosion and abrasion with quercetin-encapsulated hollow mesoporous silica nanocomposites

“…Historically, various approaches, such as calcium-containing pastes (Pei et al, 2013), sodium fluoride (Anderson et al, 2020), and laser treatment (Meng et al, 2023), have been used for tubule obstruction, but limitations persist, including shallow infiltration and the susceptibility to re-exposure during acid attack (Wang et al, 2010). Beltrame et al (2018) reported a 28% reduction in EDL with phosphorylated chitosan after 5 days of acid erosion.…”

Assessment of the Remineralizing Potential of Biomimetic Materials on Early Artificial Caries Lesions after 28 Days: An In Vitro Study

“…The oral pH levels depend upon the individual’s eating habits, oral hygiene practices, fluoride usage, and the composition and the quality of saliva and plaque [ 43 ]. For this reason, further in vitro studies and especially clinical trials are needed to validate the promising outcome of this research and clinically evaluate the remineralization efficacy of RA [ 57 , 58 , 59 ].…”

Evaluation and comparison of the effects of a new paste containing 8% L-Arginine and CaCO3 plus KNO3 on dentinal tubules occlusion and dental sensitivity: a randomized, triple blinded clinical trial study

“…The aforementioned theory is the most acceptable theory based on the dynamic flow of dentinal fluid [ 4 ]. Usually, when dentin tubules are exposed to the external environment, different stimuli can make the fluid in dentin tubules to move, which leads to nerve fiber stimulation and pain [ 5 ]. The cause of tubule exposure is multi-factorial.…”