A Randomized Double Blind Clinical Trial on a Sabgh Formulation for Patients With Vitiligo

Abstract

Background. The cosmetic problem that vitiligo produces affects patients psychologically. Many patients with vitiligo are suggested to cover their white skin patches with cosmetic products. There are formulations in traditional Iranian pharmacy to color these white skin patches. In this study, one of these formulations was compared with a cosmetic formulation. Methods. Two groups of patients were selected. One group used a marketed formulation and other group used a traditional Iranian Pharmacy formulation. The quality of life of the patients was compared based on the Dermatology Life Quality Index Questionnaire. Results. Both interventions were associated with statistically improved Dermatology Life Quality Index scores over the 8-week intervention (P < .05), although the difference between the 2 was not statistically significant (P ¼ .436). Conclusion. Traditional Iranian Pharmacy formulation is effective in increasing the quality of life in vitiligo patients.

The humanistic burden of vitiligo: a systematic literature review of quality‐of‐life outcomes

“…In general, most interventions significantly improved QoL at end of follow‐up compared with baseline 25 , 43 , 45 , 47 , 50 , 54 , 57 , 70 , 71 , 72 , 73 , 86 , 89 , 90 , 93 , 104 , 105 , 108 , 112 , 134 , 136 , 144 ; however, differences between treatment comparators within studies were rarely reported as significant. DLQI was used in the majority (23/33) of interventional studies 25 , 43 , 45 , 47 , 50 , 54 , 56 , 57 , 63 , 70 , 71 , 72 , 73 , 86 , 89 , 90 , 91 , 93 , 98 , 101 , 104 , 105 , 108 ; meaningful score changes (4‐point score reduction) 150 were achieved with ≥1 treatment arm in 10 studies. 25 , 45 , 47 , …”

“…The DLQI was administered in 80 studies 15 , 21 , 22 , 25 , 26 , 28 , 30 , 35 , 36 , 37 , 38 , 39 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ...…”

“…Tables 3 and S2 summarize findings from interventional studies (in dermatology‐ and vitiligo‐specific and generic instruments respectively), including the effects of pharmaceutical treatment, phototherapy, photochemotherapy, surgical treatment, climatotherapy, homeopathic/natural treatment, camouflage and counselling on QoL. In general, most interventions significantly improved QoL at end of follow‐up compared with baseline 25 , 43 , 45 , 47 , 50 , 54 , 57 , 70 , 71 , 72 , 73 , 86 , 89 , 90 , 93 , 104 , 105 , 108 , 112 , 134 , 136 , 144 ; however, differences between treatment comparators within studies were rarely reported as significant. DLQI was used in the majority (23/33) of interventional studies 25 , 43 , 45 , 47 , 50 , 54 , 56 , 57 , 63 , 70 , 71 , 72 , 73 , 86 , 89 , 90 , 91 , 93 , 98 , 101 , 104 , 105 ,…”

“…The DLQI was administered in 80 studies 15,21,22,25,26,28,30,35–39,43–110 ; the instrument can be administered to patients ≥16 years old. Among studies that reported a total DLQI mean score for the overall population, mean scores ranged from 1.82 to 15.0 15,21,22,26,28,35–39,44,46–48,50,51,57–62,64–68,70,71,74,75,77–80,83–85,89,91,94,97,99,100,103–105,107,110 ; as such, vitiligo effects on the lives of patients ranged from no effects to very large effects (Fig.…”

“…24,107 Effects of interventions on QoL in patients with vitiligo Tables 3 and S2 summarize findings from interventional studies (in dermatology-and vitiligo-specific and generic instruments respectively), including the effects of pharmaceutical treatment, phototherapy, photochemotherapy, surgical treatment, climatotherapy, homeopathic/natural treatment, camouflage and counselling on QoL. In general, most interventions significantly improved QoL at end of follow-up compared with baseline 25,43,45,47,50,54,57,[70][71][72][73]86,89,90,93,104,105,108,112,134,136,144 ; however, Systematic review of vitiligo quality-of-life outcomes Systematic review of vitiligo quality-of-life outcomes differences between treatment comparators within studies were rarely reported as significant. DLQI was used in the majority (23/33) of interventional studies 25,43,45,47,50,54,56,57,63,[70][71][72][73]86,[89][90][91]93,…”