2021
DOI: 10.21203/rs.3.rs-809898/v1
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A Randomized Double-Blind Cross-Over Trial to Study the Effects of Resistant Starch Prebiotic in Chronic Kidney Disease (ReSPECKD)

Abstract: Background: Chronic kidney disease (CKD) is associated with a reduced quality of life and an increased risk of kidney failure, cardiovascular events, and all-cause mortality. Accumulation of nitrogen-based uremic toxins leads to worsening of symptoms in individuals with CKD. Many uremic toxins, such as indoxyl and p-cresol sulphate, are produced exclusively by the gut microbiome through the proteolytic digestion of aromatic amino acids. Strategies to reduce the production of these toxins by the gut microbiome … Show more

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