A randomized double-blind placebo controlled pilot study of probiotics in adolescents with severe obesity

Verma, Arushi; Nelson, Maria T.; DePaolo, R. William; Hampe, Christiane S.; Roth, Christian

doi:10.1007/s40200-021-00855-7

Cited by 11 publications

(10 citation statements)

References 47 publications

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“…The randomized allocation of participants was mentioned in all included trials. However, only five trials described randomized sequence generation methods ( 16 , 17 , 19 , 21 , 23 ), and six trials reported allocation concealment ( 16 , 17 , 19 , 21 – 23 ). With the exception of Ipar’s study ( 20 ), which used an open-label design, the remaining seven studies had a low risk of blinding bias among participants, researchers, and outcome assessors.…”

Section: Resultsmentioning

confidence: 99%

“…The effect of probiotics on weight was analyzed by five studies ( 16 , 17 , 20 , 21 , 23 ), 132 in the experimental group and 120 in the control group. The meta-merge heterogeneity was significant ( I 2 = 68%, P =0.01), and the random effect model was applied to merge, as shown in Figure 3A .…”

Section: Resultsmentioning

confidence: 99%

“…The effect of probiotics on CRP was analyzed by four studies ( 17 , 20 , 21 , 23 ), 101 in the experimental group and 89 in the control group. There was no significant heterogeneity after performing meta-merge ( I 2 = 0%, P = 0.77), and the fixed-effects model was applied for merging, as shown in Figure 6A , with WMD and 95% CI -0.80 (-1.13, -0.47) mg/L, which indicated that probiotic interventions could reduce CRP levels in obese adolescents.…”

Section: Resultsmentioning

confidence: 99%

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A meta-analysis of the therapeutic effect of probiotic intervention in obese or overweight adolescents

Duan,

Wang,

et al. 2024

Front. Endocrinol.

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Background & aimsExisting evidence on the possible effects of probiotics on obese or overweight adolescents has not been fully established. Therefore, the aim of this study was to explore the effects of probiotic supplementation on anthropometric indices, inflammatory markers and metabolic indices in obese or overweight adolescents.MethodsThe literature up to March 2023 related to probiotic intervention in obese or overweight adolescents was searched and screened from multiple databases, including the CNKI(China national knowledge infrastructure), CBM(Chinese biomedical literature database), PubMed, EmBase, and Cochrane library databases. All randomized controlled trials using probiotic supplements in obese or overweight adolescents were included in this systematic review and meta-analysis.ResultsA total of 8 studies that met the inclusion criteria were included in this study. There were 201 cases in the experimental group (probiotic treatment) and 190 cases in the control group. Compared to the control group, probiotic intervention in adolescents resulted in a decrease in body mass index, fasting blood glucose and C-reactive protein with WMD(Weighted mean difference) and 95% CI of -2.53 (-4.8 to -0.26) kg/m2, -0.80 (-1.13 to -0.47) mol/L and -0.24 (-0.43 to -0.05) mg/L, respectively. No significant changes were found in weight, waist circumference, waist-to-hip ratio, insulin, Homeostatic Model Assessment of insulin resistance, interleukin 6, tumor necrosis factor alpha and so on; however, an unfavorable elevated effect in total cholesterol, triglycerides, and low-density lipoproteins was detected with WMD and 95% CI of 0.06 (0.02 to 0.09) mmol/L, 0.18 (0.14 to 0.21) mmol/L, and 0.19 (0.18 to 0.20) mmol/L, respectively.ConclusionAccording to our results, probiotic supplementation was beneficial in managing metabolic indicators such as fasting blood glucose, body mass index and inflammation-related C-reactive protein in overweight or obese adolescents. Further large scale studies are warranted to confirm present findings and to identify the effects and mechanisms to provide more precise evidence for clinical intervention.Systematic review registrationdoi: 10.37766/inplasy2024.1.0081, identifier INPLASY202410081.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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A meta-analysis of the therapeutic effect of probiotic intervention in obese or overweight adolescents

Duan,

Wang,

et al. 2024

Front. Endocrinol.

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“… 26 The ESPEN guidelines recommended using Vivomixx® in patients with mild to moderate ulcerative colitis (UC), confirming its efficacy in protecting the gut barrier and normalizing gut flora. 27 Vivomixx® was found to decrease the gut microbial Firmicutes to Bacteroidetes (F/B) ratio (representing dysbiosis markers) in obese adolescents 28 as well as in mice. 29 In CF patients, decreased levels of Bacteroidetes and Firmicutes were found compared to healthy controls, while reduced microbial richness correlated with intestinal inflammation.…”

Section: Discussionmentioning

confidence: 99%

The effect of probiotic administration on metabolomics and glucose metabolism in CF patients

Gur

Levin

Masarweh

et al. 2022

Pediatric Pulmonology

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Background and objectives: Cystic fibrosis (CF)-related diabetes (CFRD) affects 50% of CF adults. Gut microbial imbalance (dysbiosis) aggravates their inflammatory response and contributes to insulin resistance (IR). We hypothesized that probiotics may improve glucose tolerance by correcting dysbiosis. Methods: A single-center prospective pilot study assessing the effect of Vivomixx ® probiotic (450 billion/sachet) on clinical status, spirometry, lung clearance index (LCI), and quality of life (QOL) questionnaires; inflammatory parameters (urine and stool metabolomics, blood cytokines); and glucose metabolism (oral glucose tolerance test [OGTT]), continuous glucose monitoring [CGM], and homeostasis model assessment of IR (HOMA-IR) in CF patients. Results: Twenty-three CF patients (six CFRD), mean age 17.7 ± 8.2 years. After 4 months of probiotic administration, urinary cysteine (p = 0.018), lactulose (p = 0.028), arabinose (p = 0.036), mannitol (p = 0.041), and indole 3-lactate (p = 0.046) significantly increased, while 3-methylhistidine (p = 0.046) and N-acetyl glutamine (p = 0.047) decreased. Stool 2-Hydroxyisobutyrate (p = 0.022) and 3-methyl-2-oxovalerate (p = 0.034) decreased. Principal component analysis, based on urine metabolites, found significant partitions between subjects at the end of treatment compared to baseline (p = 0.004). After 2 months of probiotics, the digestive symptoms domain of Cystic Fibrosis Questionnaire-Revised improved (p = 0.007). In the nondiabetic patients, a slight decrease in HOMA-IR, from 2.28 to 1.86, was observed. There was no significant change in spirometry results, LCI, blood cytokines and CGM. Conclusions: Changes in urine and stool metabolic profiles, following the administration of probiotics, may suggest a positive effect on glucose metabolism in CF. Larger long-term studies are needed to confirm our findings. Understanding

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“…No significant change in the fasting insulin, HOMA-IR, or serum and stool inflammatory markers were noted between the two groups. One participant in the treatment arm reported adverse effects of gastrointestinal intolerance [ 160 ].…”

Section: Nutritional Strategies For Modulation Of Insulin Resistancementioning

confidence: 99%

The Effect of Healthy Lifestyle Strategies on the Management of Insulin Resistance in Children and Adolescents with Obesity: A Narrative Review

et al. 2022

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Childhood obesity is characterized by an increased risk of several metabolic derangements including insulin resistance (IR). The strongest recommendations to prevent obesity and related complications are a balanced and adequate diet and practicing physical activity from early childhood. In this review, we propose to present the effects of healthy lifestyle strategies, including physical exercise and dietary approaches, on the management of IR and related metabolic derangements. All types of exercise (aerobic, resistance and combined training) effectively reduce IR in pediatric patients with obesity; it seems that aerobic and combined training stimulate greater improvements in IR compared to resistance training. Balanced normocaloric or hypocaloric dietary approaches are also valid strategies to address IR; it is not possible to assess the long-term impact of varying macronutrients on cardiometabolic risk. The glycemic index/load evaluation is a useful dietary approach to glucose metabolism control. Similarly, they should adopt the principle of the Mediterranean diet. Randomized studies with longer monitoring are needed to define the benefits of nutritional supplementation on IR. Considering that healthy style acquisition could track to later ages, programs of healthy lifestyle starting with children offer a better preventive strategy to preserve metabolic control and children’s health.

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A randomized double-blind placebo controlled pilot study of probiotics in adolescents with severe obesity

Cited by 11 publications

References 47 publications

A meta-analysis of the therapeutic effect of probiotic intervention in obese or overweight adolescents

A meta-analysis of the therapeutic effect of probiotic intervention in obese or overweight adolescents

The effect of probiotic administration on metabolomics and glucose metabolism in CF patients

The Effect of Healthy Lifestyle Strategies on the Management of Insulin Resistance in Children and Adolescents with Obesity: A Narrative Review

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