A Randomized Double-Blind, Placebo Controlled, Four-Arm Parallel Study Investigating the Effect of a Broad-Spectrum Wellness Beverage on Mood State in Healthy, Moderately Stressed Adults

Evans, Malkanthi; Antony, Joseph M.; Guthrie, Najla; Landes, Bernie; Aruoma, Okezie I.

doi:10.1080/07315724.2017.1393356

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…(86). Given that dietary supplements may fill a void by providing necessary nutrients for optimizing health, enhancing micronutrient and vitamin levels may be a more pragmatic approach to address stress and improve psychosocial mood than pharmacological interventions with their associated negative side effects (87). Environmental factors possibly include inorganic and organic hazards, exposure to toxic metals (aluminum, copper), pesticides (organochlorine and organophosphate insecticides), industrial chemicals (flame retardants) and air pollutants (particulate matter).…”

Section: A Nutrigenomics Perspective and Emerging Nutraceuticals Targmentioning

confidence: 99%

Alzheimer’s Disease and Parkinson’s Disease: A Nutritional Toxicology Perspective of the Impact of Oxidative Stress, Mitochondrial Dysfunction, Nutrigenomics and Environmental Chemicals

Agnihotri

Aruoma

2019

Journal of the American College of Nutrition

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105

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Introduction: Alzheimer's disease is primarily a dementia-related disorder from progressive cognitive deterioration and memory impairment, while Parkinson's disease is primarily a movement disorder illness having movement disorder symptoms, bradykinesia (slowness of movements), hypokinesia (reduction of movement amplitude), and akinesia (absence of normal unconscious movements) along with muscle rigidity and tremor at rest. While aging is the main risk factor, epidemiological evidence suggests that the exposure to environmental toxicants, mainly pesticides, metals and solvents could increase the risk of developing neurodegenerative conditions. Oxidative stress in neurodegenerative diseases: Mitochondria function impacts cell respiratory processes, metabolism, energy production, intracellular signaling, free radical production, and apoptosis. In neurodegenerative diseases, mitochondrial dysfunction is associated with a compromised energy production, impaired calcium buffering, activation of proteases and phospholipases, and increased oxidative stress. Oxidative stress induced microglial cells activation, protein aggregation, neuroinflammation and mitochondrial dysfunction lead to neuronal deaths in these disorders. Role of nutrition: Neurodegenerative disease is not curable, but treatment is available to manage the symptoms and slow down the disease progression. The drugs for treating these diseases only reduce the cognitive impairment and behavioral problems, but do not stop the progression of neurodegeneration. Healthy diet, lifestyle improvement and nutraceuticals targeting of oxidative stress, inflammation, abnormal mitochondrial dynamics and the mitochondrial interaction with abnormal diseaserelated proteins and assessment of impact of environmental contaminants including occupational exposures to pesticides, can be a promising approach in the treatment of neurodegenerative diseases. Conclusion: These innovations can be benchmarked on firm understanding of nutrigenomics and the personalized management of individuals at risk.

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Section: A Nutrigenomics Perspective and Emerging Nutraceuticals Targmentioning

confidence: 99%

Alzheimer’s Disease and Parkinson’s Disease: A Nutritional Toxicology Perspective of the Impact of Oxidative Stress, Mitochondrial Dysfunction, Nutrigenomics and Environmental Chemicals

Agnihotri

Aruoma

2019

Journal of the American College of Nutrition

Self Cite

105

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Safety evaluation of kaempferol glycosides-rich standardized roasted goji berry leaf extract

Lee

Lee²,

Ryu³

et al. 2023

Regulatory Toxicology and Pharmacology

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A Randomized Double-Blind, Placebo Controlled, Four-Arm Parallel Study Investigating the Effect of a Broad-Spectrum Wellness Beverage on Mood State in Healthy, Moderately Stressed Adults

Cited by 2 publications

References 27 publications

Alzheimer’s Disease and Parkinson’s Disease: A Nutritional Toxicology Perspective of the Impact of Oxidative Stress, Mitochondrial Dysfunction, Nutrigenomics and Environmental Chemicals

Alzheimer’s Disease and Parkinson’s Disease: A Nutritional Toxicology Perspective of the Impact of Oxidative Stress, Mitochondrial Dysfunction, Nutrigenomics and Environmental Chemicals

Safety evaluation of kaempferol glycosides-rich standardized roasted goji berry leaf extract

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