A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of a Mouthwash Containing Glycyrrhiza uralensis Extract for Preventing Dental Caries

Kim, Yu-Rin; Nam, Seoul-Hee

doi:10.3390/ijerph19010242

Cited by 9 publications

(5 citation statements)

References 34 publications

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“…Moreover, licorice extract has antimicrobial effects on bacterial pathogens, such as S. aureus [38] and Streptococcus mutans, a main oral pathogen causing dental caries [39]. In a clinical trial, mouthwash containing licorice extract inhibited oral pathogens effectively [40]. The findings in this study suggest that licorice extract can possibly be used as a drug potentiator to improve the efficacy of antimicrobial therapy for treating listeriosis.…”

Section: Discussionmentioning

confidence: 68%

Antimicrobial Synergy between Aminoglycosides and Licorice Extract in Listeria monocytogenes

et al. 2022

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Listeria monocytogenes is a foodborne pathogen that can develop serious invasive infections. Among foodborne pathogens, L. monocytogenes exhibits the highest case fatality despite antibiotic treatment, suggesting the current therapy should be improved. Although ampicillin and gentamicin are used as a combination therapy to treat listeriosis, our results showed there is no synergy between the two antibiotics. We discovered that aqueous extract of licorice generated significant antimicrobial synergy when combined with aminoglycosides, such as gentamicin, in L. monocytogenes. In the presence of 1 mg/mL licorice extract, for instance, the minimum inhibitory concentration (MIC) of gentamicin was reduced by 32-fold. Moreover, antimicrobial synergy with licorice extract made gentamicin-resistant clinical isolates of L. monocytogenes susceptible to gentamicin. Given the common use of licorice as a food sweetener in Western countries and a herb in Oriental medicine, our findings suggest that licorice extract can be potentially used as an antibiotic adjuvant to improve the efficacy of antimicrobial treatment of listeriosis.

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Section: Discussionmentioning

confidence: 68%

Antimicrobial Synergy between Aminoglycosides and Licorice Extract in Listeria monocytogenes

et al. 2022

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“…The mouthwash also showed excellent effect of inhibiting bacteria that cause dental caries. Compared to dental clinical studies on Glycyrrhiza uralensis extract 17 and Sambucus williamsii var. coreana extract 18 for S. mutans, which are the most common cause of dental caries, S. mutans was not detected at all in the mandibular from immediately after gargle of Lespedeza cuneate extract used in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, dental clinical research is being conducted to evaluate the effect of using mouthwash containing natural substances on preventing dental caries. It was found that a mouthwash containing Glycyrrhiza uralensis extract can prevent dental caries and also lower the risk of dental caries 17 . In addition, a study by Kim and Nam reported that a natural mouthwash containing Sambucus williamsii var.…”

mentioning

confidence: 99%

Effects of a mouthwash containing Lespedeza cuneata extract on risk of dental caries: a randomized, placebo-controlled clinical trial

Kim

Nam

2022

Sci Rep

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This study aims to evaluate the anti-caries effect of a mouthwash containing Lespedeza cuneata extract by confirming its effect on acid-producing capacity and bacteria causing dental caries in the oral cavity. For the same oral environments of 95 subjects who agreed to participate in this study, scaling was performed one week before the experiment. The final number of subjects included in the analysis was 82, excluding those who dropped out during the study period. A randomized placebo-controlled trial was conducted by dividing the subjects into the Lespedeza cuneata extract gargle group (n = 42) and the saline gargle group (n = 40). Participants in each group gargled once every day before going to bed for 5 days, and data were collected by measuring 3 times: before gargling (Baseline), immediately after gargling (Treatment), and 5 days after gargling (After 5 Days). Two trained dental hygienists confirmed the dental caries activity through the Cariview test under the guidance of a dentist. Microbiological analysis was performed to evaluate the changes in bacteria causing dental caries. By confirming the anti-caries effect in the oral environment according to the application of Lespedeza cuneata extract gargle, dental caries activity was found to be significantly lower from Treatment to After 5 Days (p < 0.05). Dental caries-causing bacteria in the upper and lower jaws were also significantly reduced (p < 0.05). These results confirm that Lespedeza cuneata extract is a natural substance with an anti-caries effect. Gargling with a mouthwash containing Lespedeza cuneata extract is useful in preventing dental caries and inhibiting its progression. The same mouthwash can also be used as an effective formulation for maintaining and promoting oral health.

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“…In addition, there are plenty of oral non-developmental problems associated with MMP production and activity. Dental caries is a prominent multifactorial condition affecting the teeth, caused directly by microorganisms [ 95 , 96 , 97 ]. It is a progressive destruction of hard tooth tissues (enamel and dentine), involving demineralization of the inorganic parts as well dissolution of the organic components [ 98 ].…”

Section: A Brief Glance At the Role Of Matrix Metalloproteinases In T...mentioning

confidence: 99%

Matrix Metalloproteinases in the Periodontium—Vital in Tissue Turnover and Unfortunate in Periodontitis

Radzki,

Negri,

Kusiak

et al. 2024

IJMS

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The extracellular matrix (ECM) is a complex non-cellular three-dimensional macromolecular network present within all tissues and organs, forming the foundation on which cells sit, and composed of proteins (such as collagen), glycosaminoglycans, proteoglycans, minerals, and water. The ECM provides a fundamental framework for the cellular constituents of tissue and biochemical support to surrounding cells. The ECM is a highly dynamic structure that is constantly being remodeled. Matrix metalloproteinases (MMPs) are among the most important proteolytic enzymes of the ECM and are capable of degrading all ECM molecules. MMPs play a relevant role in physiological as well as pathological processes; MMPs participate in embryogenesis, morphogenesis, wound healing, and tissue remodeling, and therefore, their impaired activity may result in several problems. MMP activity is also associated with chronic inflammation, tissue breakdown, fibrosis, and cancer invasion and metastasis. The periodontium is a unique anatomical site, composed of a variety of connective tissues, created by the ECM. During periodontitis, a chronic inflammation affecting the periodontium, increased presence and activity of MMPs is observed, resulting in irreversible losses of periodontal tissues. MMP expression and activity may be controlled in various ways, one of which is the inhibition of their activity by an endogenous group of tissue inhibitors of metalloproteinases (TIMPs), as well as reversion-inducing cysteine-rich protein with Kazal motifs (RECK).

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A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of a Mouthwash Containing Glycyrrhiza uralensis Extract for Preventing Dental Caries

Cited by 9 publications

References 34 publications

Antimicrobial Synergy between Aminoglycosides and Licorice Extract in Listeria monocytogenes

Antimicrobial Synergy between Aminoglycosides and Licorice Extract in Listeria monocytogenes

Effects of a mouthwash containing Lespedeza cuneata extract on risk of dental caries: a randomized, placebo-controlled clinical trial

Matrix Metalloproteinases in the Periodontium—Vital in Tissue Turnover and Unfortunate in Periodontitis

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