A randomized, double-blind, placebo-controlled, repeated-dose pilot study of the safety, tolerability, and preliminary effects of a cannabidiol (CBD)- and cannabigerol (CBG)-based beverage powder to support recovery from delayed onset muscle soreness (DOMS)

Peters, Erica N.; Yardley, Helena; Harrison, Amy; Eglit, Graham M.L.; Antonio, Jose; Turcotte, Cynthia; Bonn-Miller, Marcel O.

doi:10.1080/15502783.2023.2280113

Journal of the International Society of Sports Nutrition

2023

DOI: 10.1080/15502783.2023.2280113

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A randomized, double-blind, placebo-controlled, repeated-dose pilot study of the safety, tolerability, and preliminary effects of a cannabidiol (CBD)- and cannabigerol (CBG)-based beverage powder to support recovery from delayed onset muscle soreness (DOMS)

Erica N. Peters,

Helena Yardley,

Amy Harrison

et al.

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2024

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Cited by 6 publications

(1 citation statement)

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“…Clinical trials on cannabinoids in pain-related complaints are emerging across different medical disciplines. Research in the settings of post-ureteroscopy pain, irritable bowel syndrome, and delayed-onset muscle soreness are ongoing [107][108][109].…”

mentioning

confidence: 99%

Tetrahydrocannabinol and Cannabidiol for Pain Treatment—An Update on the Evidence

Safi,

Sobieraj,

Błaszkiewicz

et al. 2024

Biomedicines

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In light of the current International Association for the Study of Pain (IASP) clinical practice guidelines (CPGs) and the European Society for Medical Oncology (ESMO) guidelines, the topic of cannabinoids in relation to pain remains controversial, with insufficient research presently available. Cannabinoids are an attractive pain management option due to their synergistic effects when administered with opioids, thereby also limiting the extent of respiratory depression. On their own, however, cannabinoids have been shown to have the potential to relieve specific subtypes of chronic pain in adults, although controversies remain. Among these subtypes are neuropathic, musculoskeletal, cancer, and geriatric pain. Another interesting feature is their effectiveness in chemotherapy-induced peripheral neuropathy (CIPN). Analgesic benefits are hypothesized to extend to HIV-associated neuropathic pain, as well as to lower back pain in the elderly. The aim of this article is to provide an up-to-date review of the existing preclinical as well as clinical studies, along with relevant systematic reviews addressing the roles of various types of cannabinoids in neuropathic pain settings. The impact of cannabinoids in chronic cancer pain and in non-cancer conditions, such as multiple sclerosis and headaches, are all discussed, as well as novel techniques of administration and relevant mechanisms of action.

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mentioning

confidence: 99%

Tetrahydrocannabinol and Cannabidiol for Pain Treatment—An Update on the Evidence

Safi,

Sobieraj,

Błaszkiewicz

et al. 2024

Biomedicines

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Cannabinoid Therapy in Athletics: A Review of Current Cannabis Research to Evaluate Potential Real-World Cannabinoid Applications in Sport

Thompson,

Alcorn,

Neary

2024

Sports Med

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Exploring the Potential of Nonpsychoactive Cannabinoids in the Development of Materials for Biomedical and Sports Applications

Solano-Orrala,

Silva-Cullishpuma,

Díaz-Cruces

et al. 2024

ACS Appl. Bio Mater.

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This Perspective explores the potential of nonpsychoactive cannabinoids (NPCs) such as CBD, CBG, CBC, and CBN in developing innovative biomaterials for biomedical and sports applications. It examines their physicochemical properties, antiinflammatory, analgesic, and neuroprotective effects, and their integration into various biomaterials such as hydrogels, sponges, films, and scaffolds. It also discusses the current challenges in standardizing formulations, understanding long-term effects, and understanding their intrinsical regulatory landscapes. Further, it discusses the promising applications of NPCloaded materials in bone regeneration, wound management, and drug delivery systems, emphasizing their improved biocompatibility, mechanical properties, and therapeutic efficacy demonstrated in vitro and in vivo. The review also addresses innovative approaches to enhance NPC delivery including the use of computational tools and explores their potential in both biomedical and sports science contexts. By providing a comprehensive overview of the current state of research, this review aims to outline future directions, emphasizing the potential of NPCs in biomaterial science and regenerative medicine.

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A randomized, double-blind, placebo-controlled, repeated-dose pilot study of the safety, tolerability, and preliminary effects of a cannabidiol (CBD)- and cannabigerol (CBG)-based beverage powder to support recovery from delayed onset muscle soreness (DOMS)

Cited by 6 publications

References 50 publications

Tetrahydrocannabinol and Cannabidiol for Pain Treatment—An Update on the Evidence

Tetrahydrocannabinol and Cannabidiol for Pain Treatment—An Update on the Evidence

Cannabinoid Therapy in Athletics: A Review of Current Cannabis Research to Evaluate Potential Real-World Cannabinoid Applications in Sport

Exploring the Potential of Nonpsychoactive Cannabinoids in the Development of Materials for Biomedical and Sports Applications

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