A randomized, double-blind, placebo-controlled trial on the efficacy and tolerability of sertraline in Iranian veterans with post-traumatic stress disorder

Abstract

The results of this study suggest that sertraline can be an effective, safe and tolerable treatment for combat-related PTSD in Iranian veterans.

The effect of flexible cognitive–behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees: pragmatic randomised controlled clinical trial

“…41 However, the maximum dose reached in all groups treated with antidepressants was low compared with other studies. 42,43 It would have been an obvious advantage if the medicine adherence of patients and serum concentrations had been checked with blood samples.…”

Pharmacotherapy for post-traumatic stress disorder: Systematic review and meta-analysis

“…Sixteen new studies were found from our database search. [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] The remaining 35 were found in previous reviews. An additional 28 studies were identified from the NICE guidelines, of which five did not meet our inclusion criteria.…”

Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders

“…Data with fluoxetine are mixed, with both positive [960-962] and negative [963-965] RCTs (Level 1, conflicting). Similarly, RCTs with sertraline have yielded both positive [971,972,975,976,978] and negative [973,974,977] results (Level 1, conflicting). However, there appear to be sufficient data from the larger RCTs to suggest that these agents can be effective first-line options.…”