A randomized, double-blind, placebo-controlled trial of a commercial Aloe vera gel for mitigation of phototherapy side-effects in vitiligo patients

Akhdar, Marwa; Abedini, Robabeh; Tavakolpour, Soheil; Gholibeigian, Zeinab; Azizpour, Arghavan

doi:10.1016/j.hermed.2021.100442

Cited by 7 publications

(6 citation statements)

References 15 publications

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“…Therefore, patients with psoriasis often seek safe, natural skincare products and preparations to additionally support their treatment regimens [ 12 , 24 , 26 ], and medicinal plant-based cosmetics appear to offer such a chance to the affected individuals [ 27 ]. Randomized, controlled clinical trials have confirmed beneficial effects of certain medicinal plants— Aloe vera, Centella asiatica, Panax ginseng, Rubia cordifolia, Saccharum officinarum —on skin symptom alleviation in psoriasis [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. In this study, we used the extract of S. coronata .…”

Section: Discussionmentioning

confidence: 99%

Phytoecdysteroids from Serratula coronata L. for Psoriatic Skincare

et al. 2022

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Phytoecdysones from Serratula coronata seem to be promising agents for skincare in patients with psoriasis. The aim of the study was to determine the effects of creams containing the extract of S. coronata on psoriatic lesions. Creams with different formulas were prepared: 0-Lekobaza®, 1-Lekobaza®, S. coronata, 2-Lekobaza®, Salicylic acid, 3-Lekobaza®, S. coronata, Salicylic acid. After examination of skin penetration and biosafety, the designated cream was applied twice daily for 6 weeks on 72 psoriatic plaques located on elbows or knees. The lesions were assessed at baseline and follow-up of 6 weeks. The lesions area was measured, and severity of scaling, erythema, and infiltration was assessed using a 5-point scale (from 0—none to 4—very severe). Skin hydration and structure, pH, transepidermal water loss, erythema, and melanin index were analyzed instrumentally. Creams 1, 2, and 3 significantly reduced the area of psoriatic plaques. Improvement in erythema and infiltration was observed for creams 1 and 3. Creams 1–3 reduced scaling. Our study confirmed a beneficial effect of creams containing S. coronata extract on psoriatic lesions.

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Section: Discussionmentioning

confidence: 99%

Phytoecdysteroids from Serratula coronata L. for Psoriatic Skincare

et al. 2022

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“…Rarer side effects include blistering, desquamation and ulceration 47 . Acute adverse effects, particularly erythema and xerosis, can be alleviated or resolved with TCS or emollients such as Aloe Vera gel 45,48 …”

Section: Adverse Effects and Possible Complicationsmentioning

confidence: 99%

“…47 Acute adverse effects, particularly erythema and xerosis, can be alleviated or resolved with TCS or emollients such as Aloe Vera gel. 45,48 Photoaging is a chronic side effect of phototherapy, particularly with prolonged use. 47 This could lead to the appearance of freckles, wrinkles, and loss of elasticity.…”

Section: Adverse Effects and Possible Complicationsmentioning

confidence: 99%

An update and review of narrowband ultraviolet B phototherapy for vitiligo

Wang

Rodrigues

2022

Dermatological Reviews

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Vitiligo is a chronic skin condition that results in depigmentation. It affects up to 2% of the population worldwide. Phototherapy is one of the most commonly used treatment methods for vitiligo. In the last few decades, there has been an increasing popularity of narrowband ultraviolet B phototherapy (NB-UVB) over other forms of phototherapy to treat vitiligo. This paper reviews efficacy and safety of NB-UVB treatment in vitiligo, including combination therapy with topical calcineurin inhibitors, corticosteroids, vitamin D analogs, antioxidants, and fractional CO 2 laser.Advantages and limitations of home-based phototherapy as an emerging alternative to conventional hospital-based phototherapy will also be explored.

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“…Some clinical and experimental evidence suggested the usefulness of Aloe vera in wound care and wound healing for skin moisturization, promoting wound healing, thermal skin injury, and inflammatory skin pathologies [17,[23][24][25][26][27][28]. Therefore, in vitro/in vivo trials using Aloe vera gel, as a scaffold or support matrix for tissue engineering, have received considerable attention either alone or in combination with conventional drugs or natural extracts [5,11,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]. For instance, the use of fresh Aloe vera gel for 10 days to treat breast soreness and irritation in lactating women produced significant wound healing [43].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, a commercial Aloe vera gel formulated with allantoin, bisabolol, and vitamin E was used to treat patients with vitiligo after phototherapy sessions. A significant reduction of burning sensation and high reduction in scores were observed after two and eight weeks, respectively [38]. Furthermore, Aloe vera powder was used to prepare a cream to treat vaginal atrophy for menopausal women.…”

Section: Introductionmentioning

confidence: 99%

Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process

et al. 2021

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Wound healing is fundamental to restore the tissue integrity. A topical study of the influence of Aloe vera hydrogel, formulated with 1,2-propanediol (propanediol) and triethanolamine (TEA), on the skin wound-healing process was investigated in female Wistar rats. FTIR spectroscopy confirms the presence of carboxylic acid and methyl ester carboxylate groups related with important compounds that confer the hydrogel a good interaction with proteins and growth factors. SEM images show a microstructure and micro-roughness that promote a good adhesion to the wound. Therefore, the swelling kinetics and the contact angle response contribute to the understanding of the in vivo results of the animal test. The results indicated that the Aloe vera hydrogel, prepared with propanediol and TEA, together with its superficial characteristics, improve its rapid penetration without drying out the treated tissue. This produced a positive influence on inflammation, angiogenesis, and wound contraction, reducing 29% the total healing time, reaching the total closure of the wound in 15 days.

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A randomized, double-blind, placebo-controlled trial of a commercial Aloe vera gel for mitigation of phototherapy side-effects in vitiligo patients

Cited by 7 publications

References 15 publications

Phytoecdysteroids from Serratula coronata L. for Psoriatic Skincare

Phytoecdysteroids from Serratula coronata L. for Psoriatic Skincare

An update and review of narrowband ultraviolet B phototherapy for vitiligo

Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process

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