A Randomized Open-Label Comparison of the Impact of Aripiprazole Versus Risperidone on Sexual Functioning (RAS Study)

Boer, Marrit K. de; Wiersma, Durk; Bous, J; Sytema, Sjoerd; Moolen, A.E.G.M. van der; Wilffert, Bob; Hamamura, Takashi; Knegtering, Henderikus

doi:10.1097/jcp.0b013e318222bb29

Cited by 15 publications

(8 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 Knegtering et al report 7%-40% (ranging from 0% for aripiprazole to 40% for risperidone). 5,43 DEV and dry ejaculation are reportedly related to the use of several antipsychotics like thioridazine, chlorpromazine, sertindole, risperidone, and olanzapine. 5,47,[52][53][54][55][56] Although the mechanisms are not fully known, antipsychotics with α-blocking properties and possibly also calcium channel blockers are thought to be most likely to induce DEV.…”

Section: Ejaculationmentioning

confidence: 99%

“…7 Knegtering et al report 6-50% (ranging from 6% for aripiprazole to 50% for risperidone). 5,43 Medicated as well as unmedicated patients with schizophrenia often report a decrease in sexual desire. In a study by Aizenberg 1 , patients with schizophrenia reported significantly more frequent sexual desire reduction vs unaffected controls, while sexual desire was reduced in patients using antipsychotics as well as in those not using antipsychotics.…”

Section: Sexual Desirementioning

confidence: 99%

“…The reports available suggest that patients using these antipsychotics may have comparatively lower rates of sexual dysfunction. 1,[5][6][7][41][42][43]74 Besides having affinity for the dopamine receptor, antipsychotics interact with many neurotransmitter systems in the brain and other parts of the body. Affinity for the serotonergic, noradrenergic, histaminic, and cholinergic/muscarinic neurotransmitter systems differs among the various groups of antipsychotics.…”

Section: Pharmacological Mechanisms In Antipsychotic-induced Sexual Dmentioning

confidence: 99%

“…6 Knegtering et al found a comparable order (risperidone, typical antipsychotics, clozapine, olanzapine, quetiapine, aripiprazole), based on previous studies by this research group, all of which used the same design and questionnaire. 5,36,[41][42][43] In 2011, a meta-analysis was published about sexual dysfunction in psychiatric populations of patients taking antipsychotics. In contrast to other findings, it was found that quetiapine, ziprasidone, perphenazine, aripiprazole, olanzapine, risperidone, haloperidol, clozapine, and thioridazine had an incrementally increasing impact on sexual function ranging from 16% (quetiapine) to 60% (thioridazine).…”

Section: Prevalence Of Antipsychotic-induced Sexual Dysfunction In Pamentioning

confidence: 99%

“…7 Knegtering et al report 3%-46% (ranging from 3% for olanzapine to 46% for risperidone). 5,43 In studies evaluating sexual dysfunctions, orgasm is evaluated as an individual item in questionnaires. Most studies assess the degree to which the patient indicates he or she is capable of experiencing an orgasm, but some studies also noted a disturbance in the quality of the orgasm.…”

Section: Orgasmmentioning

confidence: 99%

See 4 more Smart Citations

The Facts About Sexual (Dys)function in Schizophrenia: An Overview of Clinically Relevant Findings

Boer

Castelein

Wiersma

et al. 2015

Schizophrenia Bulletin

140

115

View full text Add to dashboard Cite

A limited number of studies have evaluated sexual functioning in patients with schizophrenia. Most patients show an interest in sex that differs little from the general population. By contrast, psychiatric symptoms, institutionalization, and psychotropic medication contribute to frequently occurring impairments in sexual functioning. Women with schizophrenia have a better social outcome, longer lasting (sexual) relationships, and more offspring than men with schizophrenia. Still, in both sexes social and interpersonal impairments limit the development of stable sexual relationships. Although patients consider sexual problems to be highly relevant, patients and clinicians not easily discuss these spontaneously, leading to an underestimation of their prevalence and contributing to decreased adherence to treatment. Studies using structured interviews or questionnaires result in many more patients reporting sexual dysfunctions. Although sexual functioning can be impaired by different factors, the use of antipsychotic medication seems to be an important factor. A comparison of different antipsychotics showed high frequencies of sexual dysfunction for risperidone and classical antipsychotics, and lower frequencies for clozapine, olanzapine, quetiapine, and aripiprazole. Postsynaptic dopamine antagonism, prolactin elevation, and α 1 -receptor blockade may be the most relevant factors in the pathogenesis of antipsychotic-induced sexual dysfunction. Psychosocial strategies to treat antipsychotic-induced sexual dysfunction include psychoeducation and relationship counseling. Pharmacological strategies include lowering the dose or switching to a prolactin sparing antipsychotic. Also, the addition of a dopamine agonist, aripiprazole, or a phosphodiesterase-5 inhibitor has shown some promising results, but evidence is currently scarce.

show abstract