A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

Abstract

12 wk of NR supplementation in doses of 2000 mg/d appears safe, but does not improve insulin sensitivity and whole-body glucose metabolism in obese, insulin-resistant men. This trial was registered at clinicaltrials.gov as NCT02303483.

Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin‐resistant men

“…This supports the lack of effects of NR on insulin resistance and glucose metabolism, as previously reported (Dollerup et al . ).…”

“…Despite the wealth of preclinical data suggesting a medical merit of NR in the treatment of mitochondrial dysfunction, no clinical studies have confirmed these findings in humans. During a double-blinded, placebo-controlled clinical trial in middle-aged, obese and insulin-resistant men (Dollerup et al 2018), skeletal muscle biopsies were collected before and after 12 weeks of NR or placebo supplementation. Here, we aimed to determine if NR supplementation in humans impacts NAD + metabolism and mitochondrial respiration in skeletal muscle.…”

Aerobic and resistance exercise training reverses age‐dependent decline in NAD+salvage capacity in human skeletal muscle

“…Dietary supplementation of NR in rodents increases NAD + levels in skeletal muscle (Canto et al 2012), and improves skeletal muscle and muscle stem cell function in mice with aging or muscular dystrophy Zhang et al 2016). The potential effects of NR in human skeletal muscle are unknown, but dietary supplementation of NR in humans increases NAD + and NAD + -related metabolites in plasma, peripheral blood mononuclear cells, and urine Dellinger et al 2017;Dollerup et al 2018;Martens et al 2018).…”

Nicotinamide riboside supplementation to improve skeletal muscle mitochondrial health and whole‐body glucose homeostasis: does it actually work in humans?

“…) and one in the American Journal of Clinical Nutrition (Dollerup et al . ), Dollerup and collaborators investigated whether 12 weeks of NRS (2000 mg/day) could improve whole‐body glucose metabolism as well as skeletal muscle mitochondrial respiration and content in obese and insulin‐resistant men. In their papers, Dollerup and colleagues report data indicating that although NRS increases in urinary metabolites of NR (Dollerup et al .…”

“…In line with these findings, NRS failed to improve insulin sensitivity and glucose tolerance, as assessed using the hyperinsulinaemic–euglycaemic clamp and an oral glucose tolerance test (OGTT), respectively (Dollerup et al . , ). In addition, no effects of NRS were observed on circulating levels of pancreatic hormones (i.e.…”