A Randomized, Placebo-Controlled Trial to Assess the Safety and Acceptability of Use of Carraguard Vaginal Gel by Heterosexual Couples in Thailand

Abstract

Carraguard can safely be used an average of 2 to 3 times per week during sex and is acceptable to Thai women and men.

One Percent Tenofovir Applied Topically to Humanized BLT Mice and Used According to the CAPRISA 004 Experimental Design Demonstrates Partial Protection from Vaginal HIV Infection, Validating the BLT Model for Evaluation of New Microbicide Candidates

“…Our experimental approach for testing these six inhibitors was a single dose of the product administered prior to exposure rather than the two doses of drug administered within 24 h as used in CAPRISA 004 (1). This experimental design is based on the more standard single-dose administration prior to exposure (19,23,29,35,44,47). This approach is simpler, more cost-effective than multiple applications per sexual encounter and has been postulated to help increase adherence among women (51).…”

“…each sexual encounter" protocol has been the most common microbicide application protocol applied in clinical trials and animal model studies (19,23,29,35,38,44,47,50,52). The six additional candidate microbicides that we tested using this experimental design represent a broad spectrum of inhibitors with distinct mechanisms capable of blocking HIV infection at several different steps of the viral replication cycle from preentry to postbudding (Table 1).…”

Sulfated Xylomannans from the Red Seaweed Sebdenia Polydactyla: Structural Features, Chemical Modification and Antiviral Activity

“…The most plausible approach involves a combination of several drugs, preferentially targeting different steps in the viral infection process [36]. Because sulfated polysaccharides are safe and acceptable [37,38], development of several secondgeneration combination formulation based on firstgeneration-led candidates might be more effective [9,39,40]. The polysaccharides of the present study exhibited potent inhibitory action against HSV-1.…”

Exopolysaccharide and lactic acid bacteria: Perception, functionality and prospects

“…These approaches include the synergistic or combinatory effect of various drugs especially in the initial inhibition of viral infection steps. Since lactic acid bacteria-derived sulfated polysaccharide confer safe and acceptable status on topical applications, strategies on developing next-generation microbicides using sulfated polysaccharides alone or in combination may give much better results on curing sexually transmitted diseases in terms of their antiviral or antimicrobial potency (Bollen et al, 2008;Kilmarx et al, 2008;Brache et al, 2007;Klasse et al, 2008). A microbicide (PC-815) developed via the combined mixture formulation of carrageenan and the nucleoside reverse transcriptase inhibitor MIV-150 has confirmed its efficacy as a nextgeneration microbicide (Woolfson et al, 2000;Malcom et al, 2005).…”