A randomized placebo-controlled trial to evaluate a novel noninjectable anesthetic gel with thermosetting agent during scaling and root planing in chronic periodontitis patients

Abstract

Aim:To study the efficacy of a noninjectable anesthetic gel with a thermosetting agent in the reduction of pain during scaling and root planing (SRP) in untreated chronic periodontitis patients.Materials and Methods:This study is a randomized, double-masked, split-mouth, placebo-controlled trial. Thirty patients were enrolled who underwent SRP in a split-mouth (right side/left side) manner. Before commencement of SRP, both quadrants on each side were isolated and had a randomized gel (either placebo or test gel) placed in the periodontal pockets for 30 s. The pain was measured using numerical rating scale (NRS) and verbal rating scale (VRS).Results:The median NRS pain score for the patients treated with the anesthetic test gel was 1 (range: 0-4) as opposed to 5 (range: 3-7) in the placebo treated patients. The mean rank of pain score using NRS in test gel was 16.18 as compared to 44.82 in placebo treated sites. Hence, significant reduction in pain was found in test gel as compared to placebo using NRS (P < 0.001). The VRS showed that the majority of patients reported no pain or mild pain with a median of 1 as compared to placebo treated sites with a median of 2 suggestive of moderate pain.Conclusions:The NRS and VRS pain scores showed that the side treated with anesthetic gel was statistically more effective than the placebo in reducing pain during SRP.

Topical anesthesia for stainless steel crown tooth preparation in primary molars: a pilot study

“…Topical anesthetics have been used in clinical dentistry for minor dental procedures such as orthodontic separator placement, mini-implant placement, rubber dam clamp placement, and scaling and root planing, which can evoke pain in the absence of anesthesia. Studies have been conducted to compare the effects of topical anesthesia and infiltration anesthesia on dental pain during such procedures [ 12 13 14 15 16 17 18 19 ]. However, evidence suggesting the use of topical anesthetics for SSC tooth preparation is lacking.…”

Pain management in periodontal therapy using local anesthetics and other drugs: an integrative review

“…The most prevalent periodontal condition in these studies was chronic periodontal disease, as mentioned in 26 studies [ 15 16 17 18 19 21 24 26 27 28 30 31 32 33 34 35 36 37 38 39 40 42 43 44 45 46 ]. Surgeries such as gingivectomy and clinical crown augmentation were addressed in five studies [ 20 23 25 29 41 ].…”

“…The most prevalent study design was the parallel design, which was used in 15 studies [ 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 ], followed by the split-mouth design, which was used in 10 [ 30 31 32 33 34 35 36 37 38 39 ], and the crossover design, which was used in 7 studies [ 40 41 42 43 44 45 46 ].…”

“…The number of patients included in the studies ranged from 7 to 122. Some studies showed a higher prevalence of female participants [ 15 16 18 20 21 25 26 36 38 40 42 43 44 ], whereas others showed a higher number of male participants [ 17 19 23 26 27 31 32 33 34 35 37 39 45 46 ]. Four studies did not provide information on sex [ 22 24 29 30 ].…”

“…Regarding the study population, 12 (38%) studies did not include patients with systemic conditions, such as diabetes and hypertension [ 17 18 23 24 26 27 28 29 43 44 45 46 ], and 18 (56%) included these patients as long as the disease was controlled or did not interfere with their oral condition [ 15 19 20 21 22 25 30 31 32 33 34 35 36 37 38 39 40 42 ]. Two (6%) studies did not provide this information [ 16 41 ].…”