A randomized prospective study of cefoxitin versus piperacillin in appendicectomy

Salam, I. M. A.; Galala, K.H.Abu; Ashaal, Y. I. E.; Chandran, Vidya; Asham, N.N.; Sim, A. J. W.

doi:10.1016/0195-6701(94)90056-6

Cited by 14 publications

(16 citation statements)

References 7 publications

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“…A single-dose cefotetan was equally effective as multiple-dose cefoxitin according to the study by Liberman et al (14). (11)(12)(13)(14) and duration of IV antibiotics in cases of non-perforated appendicitis (14,15). there were no rcts found comparing different regimens of antibiotic prophylaxis specifically regarding perforated appendicitis.…”

Section: Methodsmentioning

confidence: 99%

“…Kumarakrishnan et al (12) showed that the combination of cefotaxime-metronidazole had the lowest wound infection rate compared to metronidazolegentamycin and metronidazole-ciprofloxacin. Salam et al (13) showed that prophylactic cefoxitin or piperacillin were similarly effective in minimizing the rate of wound infections. A single-dose cefotetan was equally effective as multiple-dose cefoxitin according to the study by Liberman et al (14).…”

Section: Methodsmentioning

confidence: 99%

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The use of pre- or postoperative antibiotics in surgery for appendicitis: A systematic review

2013

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Background and Aim: The aim of this study was to review the literature regarding the use of pre- and/or postoperative antibiotics in the management of appendicitis, using data obtained from PubMed and the Cochrane Library. Material and Methods: A literature search was conducted using the terms “appendicitis” combined with “antibiotics.” Studies were selected based on relevance for the evidence on prophylactic and postoperative treatment with regard to the route and duration of drug administration and the findings of surgery. Results: Patients with acute appendicitis should receive preoperative, broad-spectrum antibiotics. The use of postoperative antibiotics is only recommended in cases of perforation, and treatment should then be given intravenously, for a minimum period of 3–5 days for adult patients, until clinical signs such as fever resolve and laboratory parameters such as C-reactive protein curve and white blood cell (WBC) start to decline. Conclusion: Preoperative antibiotic prophylaxis is recommended in all patients with acute appendicitis, whereas postoperative antibiotics only in cases of perforation.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The use of pre- or postoperative antibiotics in surgery for appendicitis: A systematic review

2013

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“…In general, a second-generation cephalosporin with anaerobic activity (cefoxitin or cefotetan) or third-generation cephalosporins with partial anaerobic activity (cefotaxime) were effective, with postoperative SSI rates of <5% in most studies. 364,[375][376][377][378][379][380][381] Piperacillin 2 g was comparable to cefoxitin 2 g in a well-controlled study. 381 Metronidazole used alone was less effective than cefotaxime, with infection rates above 10%.…”

Section: Appendectomy Proceduresmentioning

confidence: 99%

Clinical practice guidelines for antimicrobial prophylaxis in surgery

Bratzler

Dellinger

Olsen

et al. 2013

American Journal of Health-System Pharmacy

1,885

1,464

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“…An analysis of the data on conventional appendectomies published between 1992 and 1998 permits us to make the following statements [12, 21, 22, 23, 24, 25, 26, 27]: (1) Antibiotic prophylaxis is essential. (2) The infection rates for children are lower than for adults.…”

Section: Discussionmentioning

confidence: 99%

Prospective Multicenter Study of Antibiotic Prophylaxis in Operative Treatment of Appendicitis

et al. 2000

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Background/Aims: A prospective, multicenter observation study was conducted to investigate the effectiveness of antibiotic prophylaxis in the operative treatment of appendicitis. Methods: Between June 1996 and May 1997, a total of 4,968 patients underwent an operation for appendicitis at 34 East German hospitals. 41.4% (n = 2,424) received perioperative antibiotic prophylaxis whereas in 58.9% of the cases this was not given. The patients who received antibiotic prophylaxis constituted a negative selection, both with regard to risk factors and to the stage of inflammation. Results: In the total test group, the rate for septic disorders of wound healing amounted to 2.5% (n = 120). The use of antibiotic prophylaxis makes it possible to significant lower the incidence of postoperative septic disorders of wound healing (p < 0.001). In both conventional (0.7% with prophylaxis vs. 3.8% without) and in laparoscopic appendectomy (0 vs. 1.0%) the rate for septic disorders of wound healing can be reduced (p < 0.001). The global comparison irrespective of possible antibiotic prophylaxis shows a significant advantage for appendectomies which started with laparoscopy (p = 0.008), but in the subgroups with prophylaxis this advantage is completely neutralized (p = 0.78). Conclusion: From this one can deduce that conventional appendectomy with antibiotic prophylaxis comprises no higher risk of wound infection than laparoscopy, since the risk of conversion exists for every operation begun by laparoscopy. These results would lead to the conclusion that antibiotic prophylaxis should be given before every appendectomy, whether by laparoscopy or conventional methods.

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A randomized prospective study of cefoxitin versus piperacillin in appendicectomy

Cited by 14 publications

References 7 publications

The use of pre- or postoperative antibiotics in surgery for appendicitis: A systematic review

The use of pre- or postoperative antibiotics in surgery for appendicitis: A systematic review

Clinical practice guidelines for antimicrobial prophylaxis in surgery

Prospective Multicenter Study of Antibiotic Prophylaxis in Operative Treatment of Appendicitis

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