A Randomized, Single-Blinded Clinical Trial Evaluating the Effect of Extracorporeal Shockwave Treatment (ESWT) as Add-On Therapy to Vacuum Erectile Device on Peyronie’s Disease

Mortensen, Jakob; Skov‐Jeppesen, Sune Møller; Ladegaard, Peter Bill Juul; Lund, Lars

doi:10.2147/rru.s325929

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…The treatment and control groups consisted of 16 participants, who received either ESWT or placebo, and were instructed to use the aforementioned form of PTT. No difference has been shown in terms of mean penile curvature, EF, or pain 88 …”

Section: Other Non‐invasive Methods Of Treatmentmentioning

confidence: 85%

“…Two more prospective studies evaluated the combined effect of combining PTT and CCH or extracorporeal shockwave therapy (ESWT), and are described in the respective chapters of the review. 40,88 Compared with other conservative treatment methods, studies investigating PTT also reported a significant increase in stretched penile length (SPL). However an improvement of curvature was not shown in a retrospective trial by Ziegenmann et al 89 Several prospective studies reported positive outcomes with PTT, although the quality of the evidence is limited due to the lack of blinding.…”

Section: Penile Traction Therapymentioning

confidence: 99%

“…The PTT resulted in approximately 18−21% mean curve reduction, significantly improved compared with the control group, and 61% of the patients in the PTT group reported a reduction in penile curvature at 6 months. Two more prospective studies evaluated the combined effect of combining PTT and CCH or extracorporeal shockwave therapy (ESWT), and are described in the respective chapters of the review 40,88 . Compared with other conservative treatment methods, studies investigating PTT also reported a significant increase in stretched penile length (SPL).…”

Section: Physical Therapymentioning

confidence: 99%

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Current trends in non‐surgical management of Peyronie's disease—A narrative review

Kozub,

Suleja,

Chłosta

et al. 2023

Andrology

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Peyronie's disease (PD) is a connective tissue disorder affecting the tunica albuginea. It can cause pain and penile deformation, and its prevalence increases with age. Although surgery is the gold standard for the chronic phase of the disease, there are several conservative treatment methods available, and the optimal management of the acute phase of the disease remains a matter of debate. In this article, we aim to summarize the recent trends in research on the subject of non‐surgical treatment of PD. The search was performed in PubMed, Scopus, and Web of Science databases and included studies in English published between 2012 and 2022 investigating the clinical outcomes of non‐surgical PD management in humans. We have identified 20 distinct conservative treatment strategies. Among the oral therapeutics, only the use of phosphodiesterase type 5 inhibitors is currently recommended for clinical use in patients with concomitant erectile dysfunction. The use of collagenase from Clostridium histolyticum is supported by the best quality evidence in terms of intralesional injections for patients suffering from significant penile curvature; however, interferon alpha‐2b can also be an option in such patients. Among other non‐invasive methods, extracorporeal shockwaves can be useful for pain reduction, and penile traction therapy can lead to a reduction in penile curvature and plaque size. Despite a wide range of non‐surgical methods available for PD treatment, the majority are not supported by sufficient scientific evidence, and the treatment efficacy is underwhelming. Further research on the subject of non‐surgical management of PD is highly warranted.

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Section: Other Non‐invasive Methods Of Treatmentmentioning

confidence: 85%

Section: Penile Traction Therapymentioning

confidence: 99%

Section: Physical Therapymentioning

confidence: 99%

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Current trends in non‐surgical management of Peyronie's disease—A narrative review

Kozub,

Suleja,

Chłosta

et al. 2023

Andrology

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“…[ 13 ] Mortensen et al studied the combined treatment of vacuum pump and ESWT, and finally recognized that ESWT is a non-invasive treatment with less side effects, but has no significant effect on the improvement of major symptoms. [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Updated recommendations on the therapeutic role of extracorporeal shock wave therapy for peyronie’s disease: systematic review and meta-analysis

Wang,

Liu,

Tang

et al. 2023

BMC Urol

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Background The therapeutic role of extracorporeal shockwave therapy (ESWT) for Peyronie’s disease (PD) has been controversial in a long term. We aimed to further evaluate the therapeutic effect of ESWT for PD on the basis of available high-quality studies. Methods The PubMed, CENTRAL and Embase databases were searched for articles published from January 1st, 2000 to December 31, 2022. Only randomized controlled trials (RCTs) using ESWT to treat PD were included. Meta-analysis and forest plots were carried out using Review Manager 5.4.1 software, and outcomes were reviewed by 2 authors independently. Using the Risk of Bias assessment form (ROB-2) by Cochrane Collaboration for quality assessment. PRISMA 2020 guidelines were used in this article to achieve the quantitative and qualitative synthesis of data. Results A total of four RCTs were included. 151 patients in the ESWT group and 150 patients in the control group. The meta-analysis results showed that ESWT could significantly reduce plaque size (OR 2.59, 95%CI 1.15 to 5.85, P = 0.02) and relieve pain (MD -1.55, 95%CI -2.46 to -0.64, P = 0.0008); but it has no significant effect on reducing the penile curvature (OR 1.93, 95%CI 0.87–4.26, P = 0.11) and improving sexual function (MD 2.6, 95%CI -1.63 to 6.83, P = 0.23), there is also no significant difference in complication rates between groups (OR 2.94, 95%CI 0.66 to 13.03, P = 0.16). The risk of bias of results is low. The limitations of this study are that the number of included studies is too small, some experimental outcomes are missing, and the expression of outcomes is not unified. Conclusions For PD, ESWT can be considered as a safe short-term treatment, which can reduce plaque size and relieve pain, but cannot improve penile curvature and sexual function. Its long-term efficacy remains to be discussed. Registration number PROSPERO (ID: CRD42023436744).

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“…49% of patients required subsequent surgical correction [85]. In a recent clinical study examining the effect of extracorporeal shock wave treatment, no additional significant results were observed from an applied combination with PP [86].…”

Section: Therapeutical Ultrasoundmentioning

confidence: 99%

Мodern Non-Invasive Methods for Treating Peyronie's Disease

Tosev

Vladeva

Dimov

2023

RS Global - World Science

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Summary: Peyronie's disease (PD) is a common disease in men that can lead to significant penile deformity and pain, erectile dysfunction, and mental health problems. So far, surgical correction with plaque removal offers the greatest likelihood of success during the stable phase of the disease. However, for men in the acute phase of PD or those with a milder deformity who choose to avoid surgery, conservative treatment methods are also available. New innovative methods are extracorporeal shock wave therapy (ESWT) and ultrasound therapy. Intralesional therapy with IFN-α2b, verapamil, and Clostridium histolyticum (CCH) collagenase can significantly reduce penile deviation (PD), but these results may not be clinically significant in men with more severe disease. Iontophoresis (EMDA, electromotive drug administration) of verapamil and cortisone have shown reductions in PD and penile pain.Penile traction therapy offers clinically significant improvement in penile length and curvature. It requires daily therapy lasting several hours. Oral therapies with substances such as L-arginine, L-citrulline, vitamin E and phosphodiesterase inhibitors are most helpful as part of a combination regimen rather than as monotherapy. Regenerative therapies with stem cells and platelet-rich plasma, as well as intralesional therapy with botulinum toxin (Botox) have not yet been well clinically studied and their possible application is currently taking place within the framework of clinical research. The combination of various oral, topical, intralesional therapies, extracorporeal shock wave therapy, ultrasound and traction therapies together with clinical psychosexual therapy if needed could provide a more effective treatment, which in turn could prevent or reduce the need for definitive reconstructive penile surgery. Materials and methods: For the purposes of the literature review, a systematic search was conducted for articles in German and English on non-invasive treatment methods for Peyronie's disease. The articles were selected according to their relevance to the given topic. The main findings were summarized and presented in tabular form.

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A Randomized, Single-Blinded Clinical Trial Evaluating the Effect of Extracorporeal Shockwave Treatment (ESWT) as Add-On Therapy to Vacuum Erectile Device on Peyronie’s Disease

Cited by 5 publications

References 21 publications

Current trends in non‐surgical management of Peyronie's disease—A narrative review

Current trends in non‐surgical management of Peyronie's disease—A narrative review

Updated recommendations on the therapeutic role of extracorporeal shock wave therapy for peyronie’s disease: systematic review and meta-analysis

Мodern Non-Invasive Methods for Treating Peyronie's Disease

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