A Randomized Study of the Effects of Gabapentin on Postamputation Pain

Nikolajsen, Lone; Finnerup, Nanna Brix; Kramp, Steffen; Vimtrup, Anne-Sofie; Keller, Johnny; Jensen, Troels Staehelin

doi:10.1097/00000542-200611000-00023

Cited by 185 publications

(107 citation statements)

References 22 publications

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“…Bone et al reported that GBP was efficacious to treat this syndrome [24] in discordance with other authors [25,26]. GBP has been used also for attenuating haemodynamic response to tracheal intubation [27,28] and on reducing postoperative delirium [28], and like an alternative to benzodiazepines in the treatment of alcohol withdrawal [29].…”

Section: Interactionsmentioning

confidence: 97%

Gabapentin and Pregabalin for the Acute Post-operative Pain Management. A Systematic-narrative Review of the Recent Clinical Evidences

Dauri¹,

Faria

Gatti³

et al. 2009

CDT

145

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Background: Gabapentin and pregabalin inhibit Ca 2+ currents via high-voltage-activated channels containing the 2 -1 subunit, reducing neurotransmitter release and attenuating the postsynaptic excitability. They are antiepileptic drugs successfully used also for the chronic pain treatment. A large number of clinical trials indicate that gabapentin and pregabalin could be effective as postoperative analgesics. This systematic-narrative review aims to analyse the most recent evidences regarding the effect of gabapentinoids on postoperative pain treatment.Methods: Medline, The Cochrane Library, EMBASE and CINHAL were searched for recent (2006)(2007)(2008)(2009) randomized clinical trials (RCTs) of gabapentin-pregabalin for postoperative pain relief in adults. Quality of RCTs was evaluated according to Jadad method. Visual analogue scale (VAS), opioid consumption and side-effects (nausea, vomiting, dizziness and sedation) were considered the most important outcomes.Results: An overall of 22 gabapentin (1640 patients), 8 pregabalin (707 patients) RCTs and seven meta-analysis were involved in this review. Gabapentin provided better post-operative analgesia and rescue analgesics sparing than placebo in 6 of the 10 RCTs that administered only pre-emptive analgesia. Fourteen RCTs suggested that gabapentin did not reduce PONV when compared with placebo, clonidine or lornoxicam. Pregabalin provided better post-operative analgesia and rescue analgesics sparing than placebo in two of the three RCTs that evaluated the effects of pregabalin alone vs placebo. Four studies reported no pregabalin effects on preventing the PONV. Conclusion:Gabapentin and pregabalin reduce pain and opioid consumption after surgery in confront with placebo, but comparisons with other standard post-operative regimens are not sufficient. Gabapentin and pregabalin seem not to have any influence on the prevention of PONV.

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Section: Interactionsmentioning

confidence: 97%

Gabapentin and Pregabalin for the Acute Post-operative Pain Management. A Systematic-narrative Review of the Recent Clinical Evidences

Dauri¹,

Faria

Gatti³

et al. 2009

CDT

145

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show abstract

“…A similar non-significant result when comparing gabapentin and placebo was found for 6-month postoperative pain. However, at the 6-month time-point, it is important to recognize that only two studies were included in the analysis [23,24]. In two studies that were excluded from Sen et al [25,26], postoperative pain scores were significantly lower in the gabapentin group compared with both the ketamine and control groups at 3-and 6-month follow-up following hysterectomy and inguinal herniorrhaphy, respectively.…”

Section: Gabapentinmentioning

confidence: 99%

Preventive Analgesia and Novel Strategies for the Prevention of Chronic Post-Surgical Pain

Clarke

Poon

Weinrib

et al. 2015

Drugs

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Chronic post-surgical pain (CPSP) is a serious complication of major surgery that can impair a patient's quality of life. The development of CPSP is a complex process which involves biologic, psychosocial, and environmental mechanisms that have yet to be fully understood. Currently perioperative pharmacologic interventions aim to suppress and prevent sensitization with the aim of reducing pain and analgesic requirement in acute as well as long-term pain . Despite the detrimental effects of CPSP on patients, the body of literature focused on treatment strategies to reduce CPSP remains limited and continues to be understudied. This article reviews the main pharmacologic candidates for the treatment of CPSP, discusses the future of preventive analgesia, and considers novel strategies to help treat acute postoperative pain and lessen the risk that it becomes chronic. In addition, this article highlights important areas of focus for clinical practice including: multimodal management of CPSP patients, psychological modifiers of the pain experience, and the development of a Transitional Pain Service specifically designed to manage patients at high risk of developing chronic post-surgical pain. Key PointsThe development of chronic post-surgical pain (CPSP) is a complex process which involves biologic, psychosocial, and environmental mechanisms.Ketamine (an NMDA antagonist) appears to be the pharmacologic agent with the most consistent positive preventive analgesic results.The variation in patient response to pharmacologic agents can be explained, in part, by genetic polymorphisms.Understanding the heritability of CPSP will be useful when developing predictive algorithms to determine the preoperative risk for developing CPSP.Psychological treatments delivered before and after surgery have the potential to influence the trajectory of CPSP from the earliest days, in combination with multimodal, preventive analgesia.

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“…Gabapentin has been demonstrated to decrease opioids consumption in postoperative as well as painful neuropathic conditions 9,10,11,12 . Antihyperalgesic properties of gabapentin are by reducing central sensitization, a pre-requisite for postoperative hyperalgesia.…”

Section: Discussionmentioning

confidence: 99%

Prophylactic Gabapentin for Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery

Roy¹

2017

IOSR JDMS

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A Randomized Study of the Effects of Gabapentin on Postamputation Pain

Abstract: Gabapentin administered in the first 30 postoperative days after amputation does not reduce the incidence or intensity of postamputation pain.

Cited by 185 publications

References 22 publications

Gabapentin and Pregabalin for the Acute Post-operative Pain Management. A Systematic-narrative Review of the Recent Clinical Evidences

Gabapentin and Pregabalin for the Acute Post-operative Pain Management. A Systematic-narrative Review of the Recent Clinical Evidences

Preventive Analgesia and Novel Strategies for the Prevention of Chronic Post-Surgical Pain

Prophylactic Gabapentin for Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery

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