A randomized trial comparing mebendazole and secnidazole for the treatment of giardiasis

Escobedo, Ángel A.; Cañete, Roberto; González, María E.; Cruz, Arturo Pareja; Cimerman, Sérgio; Almirall, Pedro

doi:10.1179/000349803235002380

Cited by 39 publications

(32 citation statements)

References 24 publications

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“…It has been reported that secnidazole in a single dose is effective in eradication of giardiasis. [13][14][15] In previous studies, we showed significant parasitologic and clinical cure in children infected with G. intestinalis 3 and increased mean hemoglobin levels after treatment with secnidazole. 16 In addition, detection of specific protein bands and serum antibody responses against Giardia species proteins by Western blotting and ELISA has been reported.…”

Section: Discussionmentioning

confidence: 99%

Antibody Response in Children Infected with Giardia intestinalis before and after Treatment with Secnidazole

Jiménez

Pinon²,

Dive³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

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Abstract. We examined 364 school children for intestinal parasites in a sub-urban zone of Caracas, Venezuela. Giardia intestinalis was the most prevalent parasite in stool samples from 34 children. Levels of IgA and IgG antibodies to G. intestinalis were assessed by enzyme-linked immunosorbent assay and Western blot before and after treatment with secnidazole. All patients were cured with a reduction of IgA antibody levels in 26 of 34 children and a reduction in IgGspecific antibody levels in 18 of 34 children. Serum of infected patients reacted with proteins of 14 kD to 137 kD. Some patients did not show a change in IgA serum reactivity for parasite proteins by Western blot after treatment. Seventeen children showed reduction of the reactivity or disappearance of protein reactivity (mainly the 14-kD, 122-kD, and 137-kD proteins). Antibody response was not related to clinical status, but quantitative and qualitative serum antibody response against G. intestinalis infection could be used to assess levels of new protein markers that decrease or disappear with successful chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Antibody Response in Children Infected with Giardia intestinalis before and after Treatment with Secnidazole

Jiménez

Pinon²,

Dive³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

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“…El tratamiento tradicional contra la giardiasis en seres humanos incluye el uso de 5-nitroimidazoles como metronidazol, tinidazol y ornidazol, que a pesar de ser una terapia efectiva en poblaciones con prevalencias altas, puede consistir del uso de una dosis oral única del medicamento que posee una baja toxicidad y relativamente pocos efectos secundarios (15), por ejemplo podría ser proporcionada mediante secnidazol (15)(16)(17). Al igual que en los exámenes entre seres humanos, se obtuvo una tasa de erradicación parasitológica del 100% después del tratamiento con una dosis única de secnidazol en gatos infectados con G. duodenalis (18).…”

Section: G I a R D I A D U O D E N A L I S ( G L A M B L I A A N D unclassified

Single dose of secnidazole treatment against naturally occuring Giardia duodenalis infection in Sakiz lambs

et al. 2014

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Objective. The purposes of this study were to determine whether secnidazole administered at a single dose of 10 mg/kg, orally, lessens or eliminates Giardia cyst shedding, and to validate the benefit of secnidazole treatment on clinical signs and faecal consistency in lambs naturally infected with Giardia duodenalis. Materials and methods. To this extent weaned 12 weeks of age lambs were selected and randomly assigned into two groups based on placebo (group C, n=7 untreated control group) or treatment (group S, n=10 lambs treated with a single dose of secnidazole at 10 mg/kg). Results. On days 0 and 10, before and after treatment, respectively, reduction in cyst excretion was determined. The faecal consistency and general health were recorded at each sampling day. Conclusions. During the study there was a high (99.98%) reduction in cyst excretion in the secnidazol treatment group compared to the positive control group on day 10, resulting in a significant (p<0.001) reduction, making secnidazole highly effective treatment option.Key words: Clinics, evaluation, lamb, secnidazol (Source: CAB). RESUMENObjetivo. El objetivo de este estudio fue determinar si la administración oral de una dosis única de secnidazol de 10mh/kg reduce o elimina la presencia de quistes de Giardia y validar el beneficio del tratamiento con secnidazol en los signos clínicos y la consistencia fecal de corderos infectados naturalmente con Giardia duodenalis. Materiales y métodos. Se seleccionaron corderos destetados de 12 semanas de edad que fueron asignados al azar a dos grupos con base a placebo (grupo C, n=7, grupo de control sin tratar) o tratamiento (grupo S, n=10 corderos con tratamiento de dosis única de secnidazol de 10 mg/kg). Resultados. En los días 0 y 10, antes y después del tratamiento, respectivamente, se determinó una merma en la excreción de quistes. La consistencia de la materia fecal y el estado general de salud fue registrado en cada muestreo diario. Conclusiones. Durante el estudio hubo una alta reducción en la excreción de quistes (99.98%) en el grupo tratado con secnidazol comparado con el grupo control positivo en el día 10, resultando en una disminución significativa (p<0.001), haciendo del tratamiento con secnizadol una opción altamente efectiva.

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“…The latter procedure was repeated for 2 times from different samples belonging to each lamb collected on day 0 by a single blinded researcher. An involvement criterion was mono infection with G. duodenalis, proved by microscopical fecal samples as reported previously (21).…”

Section: Methodsmentioning

confidence: 99%

The efficacy of chloroquine treatment against naturally occuring Giardia duodenalis infection in lambs

et al. 2016

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Objective. The aim of the present study was to determine the efficacy of Chloroquine (Cq), an antimalarial medicine, administered at a dose of 2.5 mg/kg, orally, during 5 consecutive days, in Sakiz and Merino lambs naturally infected with Giardia duodenalis. Materials and methods. To this extent weaned 10 weeks of aged lambs were enrolled and randomly assigned into two groups based on treatment (group C, n=18 lambs treated with Cq) and placebo (group P, n=8 untreated control animals). Diagnosis was based on detection of trophozoit and/or cysts on fecal flotation. Cyst count per gram feces (days 0, 3, 7 and 10) was analyzed among groups. Results. During the trial, regarding the efficacy of Cq on days 3., 7., and 10. There was significant (p<0.01) reduction in cyst excretion; whereas evaluation of mean geometric cyst excretion revealed 100% reduction. Conclusions. There was a very high (100%) reduction in cyst excretion in the Cq treatment group compared to the positive untreated control group on days 3, 7 and 10, resulting in a significant (p<0.001) reduction, making Cq, safety, and thus highly effective treatment option of lambs with naturally occuring giardiasis.Key words: Giardia duodenalis, chloroquine, lamb (Source: CAB). RESUMENObjetivo. El objetivo del presente estudio fue determinar la eficacia de la cloroquina, un medicamento contra la malaria, administrado a una dosis de 2.5 mg/kg, por vía oral, durante 5 días consecutivos, en Corderos Sakiz y Merino infectados naturalmente con Giardia duodenalis. Materiales y metodos. En esta medida destetados 10 semanas de edad fueron incluidos y asignados al azar en dos grupos sobre la base del tratamiento (grupo C, n = 18 corderos tratados con cloroquina) y placebo (grupo P, n = 8 animales de control no tratados). El diagnóstico se basa en la detección de trophozoit y/o quistes en la flotación fecal. Quiste recuento por gramo de heces (día 0, 3, 7 y 10) se analizó entre los grupos. Resultados. Respecto a la eficacia de la cloroquina en los días 3, 7 y 10 existió una reducción significativa (p<0.01) en la excreción de quistes; mientras que la evaluación de la media de la excreción Rev.MVZ Córdoba 21(2):5328-5335, 2016. ISSN: 0122-0268 ORIGINAL 5329 de quistes reveló una reducción del 100%. Conclusiones. Durante el estudio hubo una reducción del 100% en la excreción de quistes en el grupo de tratamiento con cloroquina en comparación con el grupo control no tratado positivo en los días 3, 7 y 10, lo que resulta en una disminución significativa (p<0.001) por lo que la cloroquina razonablemente es una opción de tratamiento por el costo, seguridad, y por lo tanto muy eficaz de corderos infectados naturalmente con giardiasis.

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A randomized trial comparing mebendazole and secnidazole for the treatment of giardiasis

Cited by 39 publications

References 24 publications

Antibody Response in Children Infected with Giardia intestinalis before and after Treatment with Secnidazole

Antibody Response in Children Infected with Giardia intestinalis before and after Treatment with Secnidazole

Single dose of secnidazole treatment against naturally occuring Giardia duodenalis infection in Sakiz lambs

The efficacy of chloroquine treatment against naturally occuring Giardia duodenalis infection in lambs

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