A randomized trial comparing octyl cyanoacrylate tissue adhesive and sutures in the management of facial lacerations

Dinakar, Deevish; Ellur, Sunderraj; Joseph, Vijay

doi:10.1007/s00238-019-01532-y

Cited by 4 publications

(11 citation statements)

References 8 publications

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“…Finally, the full text of 49 studies was reviewed. Eighteen articles 33,36‐52 were included in the qualitative synthesis, of which 17 33,36‐47,49‐52 were included in the quantitative synthesis. Figure 1 shows the flowchart of study retrieval and selection 22 …”

Section: Resultsmentioning

confidence: 99%

“…Among the 18 included studies, 33,[36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52] 1020 patients were enrolled and randomized to receive a CTA or sutures for skin closure. The mean age was 60.13 ± 11.34 years, being 53.31% female.…”

Section: Participantsmentioning

confidence: 99%

“…The wounds were located on the face (8 studies), 33,[36][37][38][39][40]46,48 the neck (6 studies), 43,45,47,[50][51][52] and both the face and neck (4 studies). 41,42,44,49 In the CTA group, butylcyanoacrylate (n-2-butyl, butyl, n-butyl) was applied in 4 articles, 36,38,49,51 octylcyanoacrylate (octyl-2, octyl) in 10 articles, 37,[39][40][41][42][43][44][45]47,48 ethylcyanoacrylate in 1 article, 33 a combination of butylcyanoacrylate (N-butyl, N-butyl-2), and octylcyanoacrylate (octyl-2) in 2 articles. 46,50 The type of CTA was not mentioned in 1 article.…”

Section: Participantsmentioning

confidence: 99%

“…Another 1 or 2 additional layers were applied 5 to 15 seconds apart. In the suture group, after the wound margin was held to aid in apposition and ensure adequate eversion, the skin was closed using interrupted 38,41,48,49,52 or continuous 37,46 fashion with 3-0, 43,47 4-0, 49,50,52 5-0, 36,41,46,48 6-0, 33,[36][37][38][39][40]44,46 or 8-0 48 sutures.…”

Section: Interventionmentioning

confidence: 99%

“…The closure time was recorded from when the skin was completely prepared to when the surgeon's hands were removed from the wound. Eight studies [36][37][38]44,[48][49][50]52 reported the closure time. However, the SD of 1 study 37 could not be imputed and another study 48 reported the time of skin closure per centimeter of incision without any information on the incision length.…”

Section: Closure Timementioning

confidence: 99%

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Cyanoacrylate Tissue Adhesives Compared With Sutures on Facial and Neck Wounds: A Meta‐analysis

Charoenlux,

Utoomprurkporn,

Seresirikachorn

2023

OTO Open

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ObjectiveTo compare the effectiveness between cyanoacrylate tissue adhesives (CTAs) and sutures for skin closure on the face and neck.Data SourcesEmbase, Medline, Scopus, Central, Web of Science.Review MethodsRandomized controlled trials comparing CTAs versus sutures for skin closure on the face and neck were included. Primary outcomes were cosmetic outcomes. Secondary outcomes were scar depth, scar width, pain, closure time, cost, and adverse events. Subgroup analyses were performed by wound locations, type of CTAs, type of sutures, age groups, and type of wounds. Physicians and patients evaluated the cosmetic outcomes.ResultsEighteen studies (1020 patients) were included. CTAs offered better cosmetic outcomes by Wound Registry Scale at ≤1 month (physician: mean difference [MD]: −1.50, 95% confidence interval, CI: −2.42 to −0.58). The cosmetic outcomes assessed by Visual Analog Scale were comparable at >1 to ≤3 months (physicians: standard mean difference [SMD], −0.01, 95% CI, −0.25 to 0.23, patients: SMD, −0.02, 95% CI, −0.84 to 0.79). The cosmetic outcomes by the Patient and Observer Scar Assessment Scale favored sutures at >3 to 12 months (physician: MD 4.26, 95% CI, 2.02‐6.50). Subgroup analyses revealed no differences. CTAs offered less scar depth, scar width, pain, closure time, and total cost of closure. Adverse events were similar.ConclusionBased on the wound healing process, the cosmetic outcomes exhibited a favorable inclination toward CTAs at <1 month while demonstrating comparable results between CTAs and sutures at >1 to ≤3 months. Subsequently, sutures exhibited superior cosmetic outcomes compared to CTAs at >3 to 12 months.

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Section: Resultsmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Section: Interventionmentioning

confidence: 99%

Section: Closure Timementioning

confidence: 99%

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Cyanoacrylate Tissue Adhesives Compared With Sutures on Facial and Neck Wounds: A Meta‐analysis

Charoenlux,

Utoomprurkporn,

Seresirikachorn

2023

OTO Open

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Octyl‐2‐cyanoacrylate Tissue Adhesive Closure Versus Subcuticular Suture for Post‐Auricular Incisions

Aljehani,

Salamah,

Halwani

et al. 2024

The Laryngoscope

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BackgroundSkin closure techniques in otolaryngology vary based on surgeon preference and wound site. Octyl‐2‐Cyanoacrylate may be a safe, rapid, and cost‐effective option for post‐site closure.AimThis randomized controlled trial study aimed to compare Octyl‐2‐Cyanoacrylate and conventional subcuticular sutures in ear surgeries, assessing wound closure results in both case and control groups.MethodsThis prospective, randomized, controlled, single‐blind study was conducted at Ohud Hospital from May 2021 to May 2022. Ear surgery and cochlear implantation in patients were examined, and each group was randomly assigned to receive Dermabond TM and deep layer subcuticular sutures closure. Incisions were assessed at various time points, including 3 weeks, 6 weeks, 6 months, and 1 year post‐surgery. The patient and observer Scar Assessment Scale was used, and two independent ear surgeons used the Stony Brook Scar Evaluation Scale for initial scar assessment.ResultsThis study involved 126 ear surgery and cochlear implantation patients randomized to use cyanoacrylate tissue adhesive or subcuticular suture for port site closure. The study found that tissue adhesive (OCA) was faster and more efficient than standard sutures, saving an average of 12 min per incision in each ear. Incision cosmesis showed immediate results and significant differences, and patient satisfaction with OCA wound closure was higher than standard sutures.ConclusionThe findings confirmed that cyanoacrylate tissue adhesive significantly reduced the time needed for skin closure during ear surgery and showed immediate cosmetic improvements without any documented instances of bleeding, hematoma, infection, or wound separation.Level of EvidenceThis is a randomized controlled trial, it follows Level 2 of evidence. Randomized trial or observational study with dramatic effects Laryngoscope, 2024

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Use of cyanoacrylate tissue adhesives for wound closure in the head and neck region: A systematic review

Raj

Sheng³

et al. 2022

Journal of Plastic, Reconstructive & Aesthetic Surgery

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A randomized trial comparing octyl cyanoacrylate tissue adhesive and sutures in the management of facial lacerations

Cited by 4 publications

References 8 publications

Cyanoacrylate Tissue Adhesives Compared With Sutures on Facial and Neck Wounds: A Meta‐analysis

Cyanoacrylate Tissue Adhesives Compared With Sutures on Facial and Neck Wounds: A Meta‐analysis

Octyl‐2‐cyanoacrylate Tissue Adhesive Closure Versus Subcuticular Suture for Post‐Auricular Incisions

Use of cyanoacrylate tissue adhesives for wound closure in the head and neck region: A systematic review

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