A Randomized Trial Comparing Treatments for Varicose Veins

Brittenden, Julie; Cotton, Seonaidh; Elders, Andrew

doi:10.1016/j.jvs.2014.10.030

Cited by 68 publications

(125 citation statements)

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“…Four RCTs, six publications, were identified (Rasmussen et al, 6,7 Lattimer et al, 8,9 Biemans et al 10 and Brittenden et al 11 ), all of which studied only great saphenous (GSV) VV (only Rasmussen allowed recurrent GSV VV, provided the GSV was still present in the groin). Two papers described initial results 6,8 and were followed by further publications reporting longer-term outcomes.…”

Section: Rcts Identifiedmentioning

confidence: 99%

A review of randomised controlled trials comparing ultrasound-guided foam sclerotherapy with endothermal ablation for the treatment of great saphenous varicose veins

et al. 2015

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All endovenous modalities appear to be successful and have a role in modern day practice. Although further work is required to optimise ultrasound-guided foam sclerotherapy technique to maximise anatomical success and minimise retreatment, the present level 1 evidence base shows there is no significant difference in clinical important outcomes between ultrasound-guided foam sclerotherapy and endothermal ablation. As ultrasound-guided foam sclerotherapy is less expensive, it is likely to be a more cost-effective option in most patients in most healthcare settings. Strict adherence to the treatment hierarchy recommended by National Institute for Health and Care Excellence seems unjustified.

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Section: Rcts Identifiedmentioning

confidence: 99%

A review of randomised controlled trials comparing ultrasound-guided foam sclerotherapy with endothermal ablation for the treatment of great saphenous varicose veins

et al. 2015

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“…The treatments have been described in detail elsewhere. For UGFS, foam was produced using the Tessari technique using a ratio of 0·5 ml sodium tetradecyl sulphate to 1·5 ml air (3 per cent for GSV/SSV truncal veins, 1 per cent for varicosities; maximum 12 ml foam per session).…”

Section: Methodsmentioning

confidence: 99%

Behavioural recovery after treatment for varicose veins

Cotton

MacLennan

Brittenden

et al. 2016

British Journal of Surgery

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BackgroundThe aim of this study was to assess behavioural recovery from the patient's perspective as a prespecified secondary outcome in a multicentre parallel‐group randomized clinical trial comparing ultrasound‐guided foam sclerotherapy (UGFS), endovenous laser ablation (EVLA) and surgery for the treatment of primary varicose veins.MethodsParticipants were recruited from 11 UK sites as part of the CLASS trial, a randomized trial of UGFS, EVLA or surgery for varicose veins. Patients were followed up 6 weeks after treatment and asked to complete the Behavioural Recovery After treatment for Varicose Veins (BRAVVO) questionnaire. This is a 15‐item instrument that covers eight activity behaviours (tasks or actions an individual is capable of doing in an idealized situation) and seven participation behaviours (what the individual does in an everyday, real‐world situation) that were identified to be important from the patient's perspective.ResultsA total of 798 participants were recruited. Both UGFS and EVLA resulted in a significantly quicker recovery compared with surgery for 13 of the 15 behaviours assessed. UGFS was superior to EVLA in terms of return to full‐time work (hazard ratio 1·43, 95 per cent c.i. 1·11 to 1·85), looking after children (1·45, 1·04 to 2·02) and walks of short (1·48, 1·19 to 1·84) and longer (1·32, 1·05 to 1·66) duration.ConclusionBoth UGFS and EVLA resulted in more rapid recovery than surgery, and UGFS was superior to EVLA for one‐quarter of the behaviours assessed. The BRAVVO questionnaire has the potential to provide important meaningful information to patients about their early recovery and what they may expect to be able to achieve after treatment.

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“…Помимо этого, было выявлено статистически значимое снижение выраженности симптоматики по сравнению с исходным уровнем (р<0,001). В другой работе [37] авторы определили, что время реабилитации после КИААЦ составляет около 2 дней, что не превосходило прочие методы эндовазального лечения. Однако спустя 3 мес наблюдения исследователи сообщили о постоянной окклюзии вен у 100% больных и значительном улучшении клинического состояния пациентов, подвергшихся КИААЦ, по сравнению с РЧО и ЭВЛО.…”

Section: заболевания периферических артерий и вен Peripheral Artery Aunclassified

“…В настоящее время доступны результаты только одного исследования, которое сравнивает все три миниинвазивных метода [37]. Пациенты (n=500) были разделены на группы хирургического вмешательства, РЧО, ЭВЛО и ПСУК.…”

Section: заболевания периферических артерий и венunclassified