A Randomized Trial of Topical Corticosteroids in Epithelial Healing after Keratoplasty

Effects of anti‐inflammatory drugs and preservatives on morphologic characteristics and migration of canine corneal epithelial cells in tissue culture

“…Experimental ulcers in rabbits treated with growth factors and prednisone acetate healed more quickly than ulcers treated with growth factors alone because the neutrophil infiltration was decreased and recurrent corneal erosions were prevented 14 . Post keratoplasty, topical 1% prednisolone acetate given every 2 h for eight treatments a day did not significantly delay epithelial healing in humans 9 . Dexamethasone is occasionally used in the treatment of recurrent corneal erosions in humans when the associated inflammation causes significant patient discomfort and retards epithelial wound healing 23…”

“…Situations in which treatment with corticosteroids is indicated when there is a breach in the epithelium include, but are not limited to, the following: post keratoplasty, post full thickness repair of limbal melanomas, post cataract surgery, and in the treatment of immune‐mediated peripheral ulceration of long‐haired Dachshunds 2–7 . Corticosteroids are used in humans after keratoplasty and photorefractive keratectomy, in the treatment of bacterial ulcers and inflammatory keratitis, and post cataract surgery 8–12 . A great deal of research has been carried out on the effects of corticosteroids on re‐epithlialization of corneal lesions on humans and rabbits.…”

“…A great deal of research has been carried out on the effects of corticosteroids on re‐epithlialization of corneal lesions on humans and rabbits. The results vary between drugs and species 9,10 , 13,14 …”

“…[2][3][4][5][6][7] Corticosteroids are used in humans after keratoplasty and photorefractive keratectomy, in the treatment of bacterial ulcers and inflammatory keratitis, and post cataract surgery. [8][9][10][11][12] A great deal of research has been carried out on the effects of corticosteroids on re-epithlialization of corneal lesions on humans and rabbits. The results vary between drugs and species.…”

“…The results vary between drugs and species. 9,10,13,14 Suprofen is one of several topical ophthalmic NSAIDs currently used in the treatment of inflammatory ophthalmic diseases in human and veterinary medicine. 15,16 Topical NSAIDs are primarily used pre-and postcataract surgery to prevent prostaglandin-mediated intraoperative miosis and to treat postoperative inflammation.…”