A randomized, triple‐blind, placebo‐controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity

Abstract

Background: Collagen is the primary component in human skin. With age, there is loss of skin elasticity and collagen, resulting in wrinkle formation and reduction in skin appearance. Aims: The objective of this randomized, triple-blind, placebo-controlled study was to evaluate the safety and efficacy of a hydrolyzed marine collagen (Vinh Wellness Collagen, VWC) on aspects of skin health and quality in women between 45 and 60 years of age. Patients/Methods: Assessments of skin wrinkles, elasticity, and self-reported appearance were conducted using the VISIA skin analysis system, Cutometer ® , and Skin Quality Visual Analogue Scale. Outcomes were assessed at weeks 0 (baseline), 6, and 12. Results: After 12 weeks, participants supplemented with VWC had a significant 35% reduction in wrinkle score (P = .035) from baseline. Participants in the VWC group showed a 24% greater reduction in wrinkles on the right side of the face than those on placebo. A planned subgroup analysis based on age showed women 45-54 years had a significant 20% and 10% improvement in cheek skin elasticity from baseline to week 6 (P = .016) and 12 (P = .022), respectively. At week 12, participants in the VWC group reported greater percentage improvements in overall skin score (9%) and wrinkle (15%), elasticity (23%), hydration (14%), radiance (22%), and firmness (25%) scores vs placebo. Conclusion: Supplementation with VWC was found to be safe and well-tolerated. The results of this study support the use of fish-derived hydrolyzed collagen for the improvement of skin health in an aging population.

A Review of the Effects of Collagen Treatment in Clinical Studies

“…Evans et al performed a randomized, placebo-controlled, blind study to evaluate the efficacy of hydrolyzed marine collagen on skin health in women between 45 and 60 years of age. The results supported that the use of fish-derived hydrolyzed collagen could improve skin health in an aging population [53].…”

Marine Collagen: A Promising Biomaterial for Wound Healing, Skin Anti-Aging, and Bone Regeneration

“…It was also observed that cheek skin elasticity significantly improved at 6 weeks post-treatment. Furthermore, compared to the placebo group, it was noted that in addition to elasticity and wrinkle improvements, there was a 14% improvement in hydration, 22% improvement in radiance, and a 25% improvement in skin firmness [82]. In another experiment using chronologically aged mice, topical application or oral consumption of collagen hydrolysates was shown to have positive effects on skin aging [83].…”

“…Evans et al conducted a randomized and triple-blinded clinical trial on 45-60-year-old women to demonstrate the impact of collagen from a freshwater fish on wrinkled skin and elasticity [82]. After three months of taking the collagen supplement, there was a significant reduction (35%) in wrinkles of participants compared to baseline [82]. It was also observed that cheek skin elasticity significantly improved at 6 weeks post-treatment.…”

Synergistic effect of microneedle-delivered extracellular matrix compound and radiofrequency on rejuvenation of periorbital wrinkles

“…Nowadays, many cosmetic products are focusing on the ECM components to achieve facial rejuvenation effect. These products are beneficial for repairing the broken collagen, restoring new collagen, and hydrating the tissue to help maintain the skin firm and moist (9)(10)(11). In this study, ECM-C, a product containing multiple ECM components, such as types I/III/IV/VII collagen, laminin, nidogen, and hyaluronic acid, helped to restore the firm skin barrier to sustain a youthful appearance.…”