A randomized, triple masked, placebo-controlled clinical trial for controlling childhood obesity

Abstract

A limited period of such treatment may help weight control, and might be used to encourage those children who have been refractory to weight loss for continuing the non-pharmacological programs. Our findings should be confirmed in future studies with a longer follow-up period.

Systematic Review of Metformin Use in Obese Nondiabetic Children and Adolescents

“…Fourteen trials were identified [15,16,17,18,19,20,21,22,23,24,25,26,27,28]. However, 3 studies [16,20,23] were excluded for their short duration (<6 months).…”

“…However, 3 studies [16,20,23] were excluded for their short duration (<6 months). Thus, 11 trials were selected for inclusion in this review.…”

Pharmacological Management of Obesity in Pediatric Patients

“…36 Most trials showed BMI increases between 0.1 and 1.1 kg/m 2 in placebo groups (range = −3.2 to 0.3 kg/m 2 ). [33][34][35][36][37][38][39][40][41][42][43][44] One trial evaluated long-term metformin use in adolescents. A total of 77 obese adolescents 13 to 18 years old were randomized to metformin extended-release 1000 mg twice a day or placebo for 1 year, then followed for an additional year.…”

“…43 Appropriate dose titration does not decrease efficacy but improves tolerability and compliance. [33][34][35][36][37][38][39][40][41][42][43][44] Liver and renal function remained stable in all trials. [33][34][35][36][37][38][39][40][41][42][43][44] Yanovski et al 43 reported a statistically significant reduction in vitamin B-12 with metformin treatment.…”

Untitled

“…Durchgef ü hrt wurden neben einer bundesweiten Beob achtungsstudie [10] auch interdisziplin ä r ausgerichtete Interventionsstudien, die bei Kindern (4-bis 7-j ä hrig) und bei Jugendlichen unterschiedlich angelegt sind [3,18] . International wird bei ü bergewichtigen Jugendlichen mit schlechten Interventionsergebnissen eine medikament ö se Unterst ü tzung gepr ü ft [22] . Der langfristige Erfolg derartiger Programme bedarf noch der Best ä tigung.…”