A rapid and environmentally friendly method for determination of parabens preservatives in flavors by supercritical fluid chromatography‐tandem mass spectrometry

Abstract

A rapid method for determination of parabens preservatives (methyl paraben, ethyl paraben, isopropyl paraben, propyl paraben, isobutyl paraben, and butyl paraben) in flavors was established by using supercritical fluid chromatographytandem mass spectrometry combined with dispersive solid-phase extraction.After adding methanol and primary secondary amine to the sample simultaneously, high extraction efficiency and good sample cleanup could be obtained by simple shaking. Parabens were well separated on a Chiralpak IG-3 column in 6 min by gradient elution. Recoveries from spiked blank samples at 0.5, 1.0, and 5.0 mg/kg were determined to be 88.3-106.6%with relative standard deviations less than 8.0%. All analytes achieved good linear relation (r ≥ 0.999 2). The limits of detection for all analytes ranged from 0.03 to 0.09 mg/kg and the limits of quantification from 0.11 to 0.31 mg/kg, respectively. A total of 20 actual samples were successfully analyzed by taking the proposed method. Being simple, rapid, green, and reliable, this method can be taken for the determination of parabens preservatives in flavors.

An environment-friendly approach using deep eutectic solvent combined with liquid–liquid microextraction based on solidification of floating organic droplets for simultaneous determination of preservatives in beverages

“…A variety of analytical methods for paraben determination in different matrices have been developed by high-performance liquid chromatograph (HPLC), [9][10][11] gas chromatography (GC), 12,13 HPLC-MS [14][15][16] GC-MS, 17,18 and supercritical uid chromatography-tandem mass spectrometry (SFC-MS). 19 However, conventional preconcentration approaches are timeconsuming and oen require large volumes of volatile organic solvents, which are detrimental to human health and the environment. 18 As the new generation of pretreatment technology, microextraction technology, such as solid phase microextraction (SPME) and liquid-liquid microextraction (LLME) have already been utilized for analysis of preservatives.…”