A rapid and simple diversity-oriented synthesis of novel 3-amino-2′-oxospiro [benzo[c]pyrano[3,2-a]phenazine-1,3′-indoline]-2-carbonitrile/carboxylate derivatives via a one-pot, four-component domino reaction

Preparation and characterization of new inorganic–organic hybrid catalyst H3PMo12O40/Hyd‐SBA‐15 and its application in the domino multi‐component reaction

“…Intermediate C is in close proximity to intermediate A at the surface of H 3 PMo 12 O 40 /Hyd‐SBA‐15 that resulted in the Michael addition to generating intermediate D. The amino groups distributed on the surface of H 3 PMO 12 O 40 /HYD‐SBA‐15 deprotonated hydroxy group of intermediate D to yield the nucleophile. On the other hand, coordination of nitril group of intermediate D to a molybdenum site of the H 3 PMO 12 O 40 /HYD‐SBA‐15 would activate the electrophile which is then cyclized to afford the products 5a‐l …”

“…The biological properties of organic compounds have been enhanced if at least two heterocyclic moieties present in a single molecule. Phenazines, pyrans, and indoles are attracting great attention in academic and industrial areas so the preparation of compounds incorporating all of these moieties is very important and significant . Each of these moieties has a significant biological activity to preparation medicinal scaffolds.…”

“…The heterocyclic indole and indoline have been detected in many natural and pharmaceuticals products . The use of L‐prolin and DABCO were reported for the synthesis of a spiro‐substituted pyranophenazine‐indoline. The introduction of a new synthetic method is required that use of an efficient and eco‐friendly catalyst.…”

Application of cobalt phthalocyanine as a nanostructured catalyst in the synthesis of biological henna‐based compounds

“…A number of processes have been reported for the syntheses which includes 1‐butyl‐3‐methylimidazolium hydroxide . HOAc under microwave irradiation, [Pyrr][HCOO], DABCO, DBU, Er (OTf) 3 , water under MW, [DBU] 2 [EDS], (4‐sulfobutyl)tris(4‐sulfophenyl) phosphonium hydrogen sulfate, Nano‐Fe 3 O 4 /PEG/succinic anhydride, phenylphosphinic acid, p ‐TSA …”

“…[3] A number of processes have been reported for the syntheses which includes 1-butyl-3-methylimidazolium hydroxide. [4] HOAc under microwave irradiation, [5] [Pyrr][HCOO], [6] DABCO, [7] DBU, [8] Er (OTf) 3 , [9] water under MW, [10] [DBU] 2 [EDS], [11] (4-sulfobutyl)tris(4-sulfophenyl) phosphonium hydrogen sulfate, [12] Nano-Fe 3 O 4 /PEG/succinic anhydride, [13] phenylphosphinic acid, [14] p-TSA. [15] Phthalocyanines are produced by high-temperature cyclotetramerization of phthalic acid or dicyano derivatives.…”