A rapid monitoring method for inorganic arsenic in rice flour using reversed phase-high performance liquid chromatography-inductively coupled plasma mass spectrometry

Abstract

A new rapid monitoring method by means of high performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP-MS) following the heat-assisted extraction was developed for measurement of total inorganic arsenic species in rice flour. As(III) and As(V) eluted at the same retention time and completely separated from organoarsenic species by an isocratic elution program on a reversed phase column. Therefore, neither ambiguous oxidation of arsenite to arsenate nor the integration of two peaks were necessary to determine directly the target analyte inorganic arsenic. Rapid injection allowed measuring 3 replicates within 6min and this combined with a quantitative extraction of all arsenic species from rice flour by a 15min HNO-HO extraction makes this the fastest laboratory based method for inorganic arsenic in rice flour.

Speciation Analysis of Arsenic Compounds by High-Performance Liquid Chromatography in Combination with Inductively Coupled Plasma Dynamic Reaction Cell Quadrupole Mass Spectrometry: Application for Vietnamese Rice Samples

“…Absolute LOD and LOQ of the developed method were achieved at picogram levels. LOD and LOQ of the developed method were also comparable with recent publications [9, 30]. In summary, the introduced and optimized method was fit-for-purpose regarding the quantification of arsenic compounds in rice samples.…”

“…Recently, many analytical methods have been introduced for quantification of arsenic species in the rice sample such as gas chromatography tandem mass spectrometry after appropriate derivatization steps, and liquid chromatography in combination with atomic absorption/fluorescence spectrometry (HPLC-AAS/AFS) [7, 8], liquid chromatography in combination with atomic absorption spectrometry via hydride generator (HPLC-HG-AAS), liquid chromatography in combination with inductively coupled plasma quadrupole mass spectrometry (HPLC-ICP-QMS) [6, 9, 10], gas chromatography mass spectrometry, and gas chromatography atomic emission spectrometry have been also introduced for speciation analysis of arsenic compounds in ready-to-eat rice samples [11, 12]. Moreover, a nonchromatographic separation was also introduced for analysis of inorganic arsenic in rice samples [13].…”

DNA-Gated Graphene Field-Effect Transistors for Specific Detection of Arsenic(III) in Rice

“…Currently, the commonly used methods for arsenic detection are chromatography and spectroscopy, such as high-performance liquid chromatography (HPLC), − ion chromatography (IC), gas chromatography (GC), inductively coupled plasma-mass spectrometry, and atomic fluorescence spectrometry. , However, these methods have many limitations in practical applications. For example, they generally require large equipment, complex operation, and excessive maintenance costs and are time-consuming .…”

Inorganic arsenic contents in infant rice powders and infant rice snacks marketed in Korea determined by a highly sensitive gas chromatography-tandem mass spectrometry following derivatization with British Anti-Lewisite

“…High performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP-MS), selective hydride generation-inductively coupled plasma mass spectrometry (HG-ICP-MS), HG-atomic absorption spectrometry (HG-AAS), HPLC-hyphenated with atomic absorption spectrometry (AAS) or atomic fluorescence spectrometry (HPLC-AFS) has been successfully introduced to analyze the arsenic species with a main focus on the analysis of iAs [1,5,[25][26][27][28]. Recently, in our laboratory, a highly selective and sensitive gas chromatographytandem mass spectrometry in combination with one step derivatization with British Anti-Lewisite (BAL) was successfully developed and validated for the determination of iAs content in rice and rice products [20].…”