A rapid reversed phase high-performance liquid chromatographic method for determination of sophoridine in rat plasma and its application to pharmacokinetics studies

Pharmacokinetic study of matrine, oxymatrine and oxysophocarpine in rat plasma after oral administration of Sophora flavescens Ait. extract by liquid chromatography tandem mass spectrometry

“…1), as the major ones had been investigated intensively, and were found to have antiinflammatory, antitumor, antipyretic and hepatoprotective [4][5][6][7] effects. Recently, much attention has been paid to the absorption and metabolism of quinolizidine alkaloids, and a few papers dealing with their pharmacokinetics and pharmacodynamics have been published [8][9][10][11][12][13][14][15][16] employing mainly high-performance liquid chromatography tandem mass spectrometry (HPLC-MS) [8][9][10]. It ensures high sensitivity for quantification with high degree of specificity at relatively short analytical time without a need for complete chromatographic resolution of analytes.…”

Determination of ferruginol in rat plasma via high‐performance liquid chromatography and its application in pharmacokinetics study

“…After 10 min the mixture was centrifuged for 5 min to separate precipitated proteins. The supernatant was transferred into 1.5 mL tubes containing 30 mg sodium chloride (Wei et al, 2006). The suspension was vortexmixed and left to stand for 10 min.…”

Simultaneous determination of 14-thienyl methylene matrine and matrine in rat plasma by high-performance liquid chromatography–tandem mass spectrometry and its application in a pharmacokinetic study

“…Therefore, a sensitive and accurate analytical method for the simultaneous determination of TMM and MT is required to support pharmacokinetic (PK) study. Recently, much attention has been paid to the absorption and metabolism of matrine and oxymatrine, and a few papers dealing with their pharmacokinetics and pharmacodynamics have been published [6][7][8][9][10][11][12][13][14] employing mainly high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS) [6][7][8]. It ensures high sensitivity for quantification with high degree of specificity at relatively short analytical time without a need for complete chromatographic resolution of analytes.…”