2012
DOI: 10.1590/s0004-27302012000500008
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A rare case of Cushing syndrome by cyclic ectopic-ACTH

Abstract: SUMMARYACTH-dependent Cushing syndrome (CS) due to ectopic ACTH production is most times difficult to manage. The identification of the source of ACTH may take many years. Surgery or chemotherapy for the primary tumor is not always possible. Control of Cushing symptoms is many times achieved using medication, or bilateral adrenalectomy in refractory cases. This case presents a Brazilian male who showed severe hypertension, mood changes, muscle weakness, darkening of skin, and increased abdominal fat. An invest… Show more

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Cited by 13 publications
(7 citation statements)
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“…Cyclic Cushing syndrome has been reported especially in ACTH-independent Cushing syndrome and rarely in ACTH-dependent Cushing syndrome, both in cases of microadenomas and ectopic ACTH secretion. 8,18 In the cyclic form of ACTH-dependent Cushing syndrome, the hypersecretion of ACTH shows a cyclic or intermittent pattern. As a result, serum ACTH levels together with cortisol serum levels normalize in the clinical remission phase of the disease.…”
Section: Discussionmentioning
confidence: 99%
“…Cyclic Cushing syndrome has been reported especially in ACTH-independent Cushing syndrome and rarely in ACTH-dependent Cushing syndrome, both in cases of microadenomas and ectopic ACTH secretion. 8,18 In the cyclic form of ACTH-dependent Cushing syndrome, the hypersecretion of ACTH shows a cyclic or intermittent pattern. As a result, serum ACTH levels together with cortisol serum levels normalize in the clinical remission phase of the disease.…”
Section: Discussionmentioning
confidence: 99%
“…Neuroendocrine tumors of the thymus are the most frequently represented, followed by neuroendocrine bronchial tumors [4, 1926]. Other tumors reported as responsible of cyclic ectopic CS are pancreatic, renal and gastric NET [2729], epithelial thymoma [30], phaeochromocytoma [31], carotid glomus tumor [32] and ectopic pituitary adenoma [33]. Surprisingly, although small cell lung carcinoma is frequent in patients with ectopic CS, biochemical episodes of cycling seem to be rare.…”
Section: Discussionmentioning
confidence: 99%
“…МРЩЖ является одним из самых злокачественных видов опухолей эндокринной системы [9,10]. Большая часть этих опухолей характеризуется агрессивным течением со склонностью к раннему метастазированию и рецидивированию.…”
Section: заключениеunclassified