A rare case of multicentric secretory carcinoma of breast in an adult female with review of literature

Abstract

Secretory breast carcinomas (SBCs) are considered one of the rarest types of BCs accounting for <0.15% of all breast cancers. The lesions are typically solitary, but rare multicentric cases have been reported. SBC have characteristic histopathological, immunohistochemical, and electron microscopic findings. Children and adolescents with SBC have a favorable prognosis, but disease seems slightly more aggressive in adults. The characteristic ETV6-NTRK3 molecular alteration, leading to a stable chimeric tyrosine kinase fusion product, may be the target of promising new treatment for this unique BC. We present a rare case of multicentric secretory carcinoma of breast with aggressive clinical behavior in a 75-year-old female.

Immunohistochemical expression of vimentin in invasive breast carcinoma and its correlation with clinicopathological parameters

“…However, BCa subtypes such as IDC + mucinous (1), IDC + lobular (1), and mucinous carcinoma (2) did not show vimentin expression. This is similar to studies documented in the literature 161718192021…”

Male secretory breast cancer: case in a 6-year-old boy with a peculiar gene duplication and review of the literature

“…Typically, SBC is a unicentric lesion [12,38,39] that sonographically appears as a round/oval, well-circumscribed, hypoechoic/isoechoic, usually homogeneous mass [11,12,29,[40][41][42]. At mammography, in contrast to IDC, SBC has variable non-specific features ranging from a benign-looking discrete, lobulated, solitary mass with smooth or irregular borders to suspicious asymmetric densities with spiculated margins and rarely microcalcifications [12,43,44].…”

“…Li et al reported an exceptional case of a 41-yearold man with a breast mass present from his childhood, finally diagnosed a SBC [30]. Axillary lymph node involvement is uncommon, especially in tumors less than 2 cm [12,28,33,38,60]. Studies have shown that lymph node metastasis is particularly rare in children and adolescents [44,61,62].…”

“…Therapy is controversial [63][64][65] and given the extremely good prognosis associated with SBC, several authors suggest less aggressive treatments compared to those needed for IDC [55]. However, because SBC is so rare, there is no consensus [9,10,38,40,56].…”

“…Based on expert opinion and published case series, the management of SBC is considered to be first and foremost surgical [10,38,55] without consensus regarding the optimal extent of surgery. Some authors suggest mastectomy as the most appropriate treatment in children [28] considering that local recurrence is believed to be more likely the result of incomplete excision rather than of inherent aggressiveness [47,55,66].…”