A rare case of multifocal intramedullary germinoma in cervical spinal cord

Wang, R; Fan, Xiangshan; Zhang, B

doi:10.1038/sc.2014.33

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…Primary cluding 27 cases of pure germinoma (71%), 5 cases of germinoma with syncytiotrophoblastic giant cells (STGCs) (13%), 3 cases of mixed germ cell tumor (8%), 2 cases of yolk sac tumor (5%), and 1 case of embryonal carcinoma (3%). 1,2,5,7,9,11,12,16,[19][20][21] The proportion of NGGCTs among primary spinal germ cell tumors appears slightly lower than that among intracranial germ cell tumors. 15 Among these 38 cases, 25 (66%) involved Japanese patients and 19 (50%) involved male patients.…”

Section: Primary Spinal Germ Cell Tumorsmentioning

confidence: 96%

Successful treatment of mixed yolk sac tumor and mature teratoma in the spinal cord: case report

Mukasa¹,

Yanagisawa²,

Tanaka³

et al. 2017

SPI

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Primary spinal germ cell tumors are rare, and spinal nongerminomatous germ cell tumors represent an even rarer subset for which no standard therapy has been established. The authors report the case of a 24-year-old woman with multifocal primary spinal germ cell tumors scattered from T-12 to L-5 that consisted of yolk sac tumor and mature teratoma. After diagnostic partial resection, the patient was treated with 30 Gy of craniospinal irradiation and 30 Gy of local spinal irradiation, followed by 8 courses of chemotherapy based on ifosfamide, cisplatin, and etoposide (ICE). Salvage surgery was also performed for residual mature teratoma components after the third course of ICE chemotherapy. Chemotherapy was continued after the operation, but ifosfamide was entirely eliminated from the ICE regimen because severe myelosuppression was observed after previous courses. The patient remains recurrence free as of more than 5 years after the completion of chemotherapy. This case suggests that this treatment strategy is an effective option for primary spinal yolk sac tumor.

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Section: Primary Spinal Germ Cell Tumorsmentioning

confidence: 96%

Successful treatment of mixed yolk sac tumor and mature teratoma in the spinal cord: case report

Mukasa¹,

Yanagisawa²,

Tanaka³

et al. 2017

SPI

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Primary extramedullary spinal germinoma: case report and review of the literature

Qin

et al. 2016

Neurosurg Rev

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The authors describe a case of a purely primary extramedullary spinal germinoma in a young Chinese male. Primary spinal germinoma is extremely rare tumor. Currently, less than 30 histologically verified spinal germinoma cases have been reported previously, mostly involving Asian of Japanese descent. This 24-year-old male suffered from progressive low back pain radiating to both legs. Magnetic resonance imaging showed a well-demarcated, intradural extramedullary mass at the level of L2 and L3. The lesion was totally removed and was confirmed as a germinoma. Upon histological verification of the tumor, he was treated successfully with radiotherapy and adjuvant chemotherapy. This report also reviews the literature pertaining to primary spinal germinoma. Except for 16 cases with intramedullary lesions and five cases with both intra- and extramedullary tumors, there were only three previously reported cases of extramedullary spinal germinomas, all initially presenting with sausage-like lesions. To the authors' knowledge, it is thought to be the first case of such a tumor, roughly round in shape and extramedullary location. Although rare, primary spinal germinoma do occur and should be included in the differential diagnosis of spinal tumors. Aggressive malignant behavior has been reported and close follow-up is necessary.

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