A rare entity in ED: Normal lipase level in acute pancreatitis

Limon, Önder; Şahin, Erkan Melih; Kantar, Funda Uğur; Oray, Deniz; Ugurhan, Asli Aydinoglu

doi:10.1016/j.tjem.2014.09.001

Cited by 10 publications

(11 citation statements)

References 5 publications

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“…In the literature, several cases of pancreatitis with normal lipase have been described, two of which were diagnosed in circumstances identical to those of our patient [7]. In both patients lipase was measured on several occasions and always returned normal, the diagnosis was only made afterwards by imaging.…”

Section: Discussionsupporting

confidence: 69%

Normal Lipase Pancreatitis: A Case Report

Ayoub¹,

Chouikh²,

Ababou³

et al. 2022

IJCCR

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Acute pancreatitis is a serious and potentially fatal condition, caused by the pancreas self-digesting with its own accidentally activated enzymes. its diagnosis is based on a combination of clinical, biological and radiological evidence. The absence of lipase elevation during acute pancreatitis is extremely rare and can sometimes make the diagnosis difficult and therefore delay the treatment. We will report the case of a 27-year-old female patient, with no previous history of the disease, who consulted us for acute abdominal pain, and whose diagnosis, after an etiological investigation, was pancreatitis with normal lipase levels.

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Section: Discussionsupporting

confidence: 69%

Normal Lipase Pancreatitis: A Case Report

Ayoub¹,

Chouikh²,

Ababou³

et al. 2022

IJCCR

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“…There have been case reports in the past supporting the possibility of normal lipase levels, particularly in cases of acute on chronic pancreatitis, hypertriglyceridemia induced or in late presentations, none of which fit this clinical scenario. [9][10][11][12][13]…”

Section: Discussionmentioning

confidence: 99%

Pancreatitis with a Normal Serum Lipase, a Rare Post-esophagogastroduodenoscopy Complication: A Case Report

Sturlis

McGrane

2022

Clinical Practice and Cases in Emergency Medicine

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Introduction: Pancreatitis after esophagogastroduodenoscopy (EGD) is not a common occurrence, particularly in the setting of a normal serum lipase. The lack of commonality may delay diagnosis and treatment in some patients presenting to the emergency department (ED) with abdominal pain after an otherwise uncomplicated procedure. Case Report: A patient with a history of gastroesophageal reflux disease presented to the ED with a complaint of abdominal pain and fever three days after an uncomplicated EGD. The patient was ultimately diagnosed with pancreatitis after a computed tomography showed pancreatic head inflammation, despite having a normal serum lipase. There were no other identified risk factors for pancreatitis in this case. Conclusion: This case serves to bring awareness to this potential procedural complication and the possibility of pancreatitis with a normal serum lipase.

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“…On review of literature, twenty-three published cases of AP with normal lipase levels were found available and can be accessed through PubMed search online. [4][5][6][7][8][9][10][11][12][13] All retrievable information related to demographic profile, aetiologies, outcomes, etc. are presented in Table 1.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, a few cases of AP with normal lipase levels have also been reported. [4][5][6][7][8][9][10][11][12][13] We report a similar case of AP, where serum lipase levels surprisingly remained normal throughout the course of the disease. Moreover, a brief review of all such case reports published till 2021 is presented here in a tabulated form (Table 1 and 2, and Figure 1,2,3).…”

Section: Introductionmentioning

confidence: 99%

Normal lipase acute pancreatitis: A case report and brief review of literature

2022

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Acute pancreatitis is a common presentation in Emergency Department. Elevated amylase and lipase level are one of the three important criteria to diagnose acute pancreatitis. Out of amylase and lipase, the latter is considered more specific for acute pancreatitis. We report a case of acute pancreatitis with a normal lipase level. On review of published literature on acute pancreatitis with normal lipase levels, 23 such case reports were retrieved. A brief review of all these cases including the case presented here had unknown etiology in 50% of cases followed by alcohol and gall stone. Pain abdomen was the commonest presentation followed by vomiting. The normal discharge could be done in 71% of cases and 17% of patients were non-survivors. Hence, normal lipase cannot rule out acute pancreatitis on its own. A typical presentation of acute pancreatitis needs radiological work up like an Ultrasound abdomen or CT scan with IV contrast (if not contraindicated) before refuting its possibility.

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A rare entity in ED: Normal lipase level in acute pancreatitis

Cited by 10 publications

References 5 publications

Normal Lipase Pancreatitis: A Case Report

Normal Lipase Pancreatitis: A Case Report

Pancreatitis with a Normal Serum Lipase, a Rare Post-esophagogastroduodenoscopy Complication: A Case Report

Normal lipase acute pancreatitis: A case report and brief review of literature

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