A rare large cutaneous chondroid syringoma involving a toe

Abstract

Rationale:Chondroid syringoma (CS) occurs mostly on the face and neck, and rarely occurs in the toe. Malignant CS is invasive, grows quickly, and has a high recurrence rate. The presence of a bilobed CS in 1 toe has never been reported in the literature.Patient concerns:A 72-year-old male patient presented with a mass in a third toe of his right foot. The mass had slowly grown in 2 years. He felt mild pain and the mass occupied most of the tip of the toe.Diagnoses:Radiographs showed a large soft-tissue mass in the third toe of his right foot without any bone destruction. Ultrasonogram showed 2 partly fused hypoechoic masses within the lesion. The mass was therefore diagnosed as a benign CS.Interventions:We amputated the toe with the mass under local anesthesia. The postoperative pathohistological examinations confirmed that the lesion was a bipartite CS exhibiting active cellular proliferation.Outcomes:Two years after surgery, there was no tumor recurrence.Lessons:CS can also present as multiple adjacent masses. Complete surgical resection and long-term follow-up are essential.

Mixed Eccrine Cutaneous Tumor with Folliculo–Sebaceous Differentiation: Case Report and Literature Review

“…Lesions did not recur once they had been removed in toto [ 7 ]. Malignant transformation is exceptionally rare, with only a few cases reported where additionally a long term followup is recommended, as some authors even suggest adjuvant radiotherapy [ 19 , 20 , 21 ].…”

A Rare Case of Myxochondroid Metaplasia of the Plantar Foot With Review of Histopathological Mimics

“…It is frequently encountered in the head and neck area, although plantar cases have been rarely reported. 16 Additionally, chondroid syringoma is characterized by mixed epithelial and myoepithelial cells in a chondromyxoid background. In a small subset of cases, the epithelial component might be sparse and might need a keratin stain to be visualized.…”

The Role of Radiation Therapy as an Adjuvant Treatment in Nodal Metastasis of Malignant Chondroid Syringoma

“…CSs are rare mixed skin tumors, composed of both epithelial and stromal components, originated from cells of sweat gland and ectopic salivary gland [1]. They were first described in 1961, by Hirsch and Helwig [2], and are usually located on the head and neck, asymptomatic and presenting a slow-growing, classified as a benign disease.…”

“…Nodal metastasis was observed in 39% of the cases, while distant metastases (lung, bone and brain) were observed in 36% of them. 27% of patients died from this disease within nine weeks following surgery; one patient survived 13 years after diagnosis [1,4].…”

“…Chondroid syringomas (CSs) are rare benign tumors originated from sweat gland and ectopic salivary glands. They are usually asymptomatic, indolent and occur usually in the head and neck [1,2]. Malignant chondroid syringomas (MCSs) are extremely rare and, on the other hand, are much more aggressive than the benign form and occur usually on extremities and trunk.…”