A rare pulmonary infection caused by Arthrographis kalrae

Vos, Cornelis G.; Murk, Jean Luc; Hartemink, Koen J.; Daniëls, Hans; Paul, Marinus A.; Debets-Ossenkopp, Yvette J.

doi:10.1099/jmm.0.037531-0

Cited by 21 publications

(15 citation statements)

References 9 publications

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“…Arthrographis is a hyaline mould that has been reported as a cause of pneumonia in a patient with lymphoma, 33 but to our knowledge it has not been reported as a cause of an IFI in a HSCT recipient. Our patient had multiple nodular lung opacities surrounded by halos of ground-glass opacities on CT and his BAL grew only Arthrographis sp.…”

Section: Discussionmentioning

confidence: 80%

Epidemiology and outcomes of invasive fungal infections in allogeneic haematopoietic stem cell transplant recipients in the era of antifungal prophylaxis: a single‐centre study with focus on emerging pathogens

Corzo-León

Satlin

Soave

et al. 2015

Mycoses

102

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With increased use of expanded-spectrum triazoles for antifungal prophylaxis, the epidemiology of invasive fungal infections (IFIs) after allogeneic haematopoietic stem cell transplantation (HSCT) continues to evolve. To define the contemporary epidemiology of IFIs in this population, we reviewed all European Organization for Research and Treatment of Cancer-Mycoses Study Group proven and probable IFIs in adults transplanted from 2002 to 2011 and determined the incidence and risk factors for IFI and post-IFI mortality. All patients received antifungal prophylaxis. Fifty-three (14%) of 378 allogeneic HSCT recipients developed an IFI. There were 62 IFI episodes, of which aspergillosis (n = 31; 50%) and candidaemia (n = 15; 24%) were most common. Sixteen episodes (26%) were caused by other fungi, including Mucorales (n = 6; 10%) and the following uncommon pathogens: Trichosporon asahii, Arthrographis sp., Cladosporium sp., Geosmithia argillacea and Hormographiella aspergillata. Independent IFI risk factors were hospitalisation in an intensive care unit [ICU; odds ratio (OR) = 6.0], graft-versus-host disease (OR = 5.3), central venous catheter use (OR = 5.2) and hypoalbuminaemia (OR = 0.3 g(-1) dl(-1) increase in albumin). The 90-day mortality rate after IFI was 57%. Non-cytomegalovirus systemic viral co-infection (OR = 3.5) and stay in an ICU (OR = 2.9) were independent risk factors for death. Despite antifungal prophylaxis, IFIs remain common after allogeneic HSCT and previously uncommon pathogens are emerging.

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Section: Discussionmentioning

confidence: 80%

Epidemiology and outcomes of invasive fungal infections in allogeneic haematopoietic stem cell transplant recipients in the era of antifungal prophylaxis: a single‐centre study with focus on emerging pathogens

Corzo-León

Satlin

Soave

et al. 2015

Mycoses

102

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“…Currently, one case of infection with Arthrographis sp. and 14 cases of infection with A. kalrae have been reported (Table 1): two onychomycosis [2], [3], one mycetoma [4], five keratitis [5], [6], [7], [8], [9] one of which associated with sinusitis [8], two knee joint infection [10], [11], one endocarditis [12], two pulmonary infections [13], [14], one meningitis [15] and one fungal stroke [16]. These cases have a worldwide distribution: seven cases in Europe, one in China, one in Japan, three in USA, one in Mexico, one in Malaysia and one in Australia.…”

Section: Discussionmentioning

confidence: 99%

First case of Arthrographis kalrae fungemia in a patient with cystic fibrosis

Denis

Sabou

Degot

et al. 2016

Medical Mycology Case Reports

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Arthrographis kalrae is a hyalin fungus. It is a saprophyte of the environment, mainly found in soil and compost. In recent years, cases of opportunistic infections attributed to this pathogen have been described. Our patient was a 19-year-old woman with cystic fibrosis. She presented a bacterial and fungal pulmonary colonization with Aspergillus fumigatus and Arthrographis. kalrae. After her lung transplantation, she developed an A. kalrae fungemia, treated with caspofungin 50 mg/day associated to liposomal amphotericin B i.v. 3 mg/kg/day. The patient died 8 months after her transplantation as the result of a bacterial septic shock.

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“…It is rarely reported as a cause of mycetoma, septic arthritis, sinusitis, meningitis, pneumonia, bronchopleural fistula, and onychomycosis. [99][100][101][102] There are two case reports of A. kalrae infection in patients with CF, causing pneumonia and fungemia, respectively. 103,104 The radiographic appearance of A. kalrae may resemble that of Aspergillus species.…”

Section: Epidemiology and Clinical Manifestationsmentioning

confidence: 99%

Non-Aspergillus Hyaline Molds: Emerging Causes of Sino-Pulmonary Fungal Infections and Other Invasive Mycoses

Jacobs

Wengenack

Walsh

2020

Semin Respir Crit Care Med

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Hyaline molds, widely distributed in nature, are an important and increasing cause of invasive fungal infections in humans, likely due to an expanding population of immunosuppressed hosts, increases in antifungal resistance, and improvements in laboratory diagnostics. Sinopulmonary disease and disseminated infection are common manifestations in neutropenic patients and transplant recipients, whereas, catheter-related and localized soft tissue infections predominate in immunocompetent hosts. These organisms are not reliably differentiated based on their morphology in tissue; rather, efforts should be made to establish a microbiologic diagnosis via culture or molecular-based methods to guide antifungal management and inform prognosis. Herein, we review the epidemiology, clinical manifestations, diagnosis, and management of these opportunistic pathogens known to cause hyalohyphomycoses: Scedosporium spp., Lomentospora prolificans, Fusarium spp., Scopulariopsis spp., Arthrographis kalrae, Trichoderma spp., Acremonium spp., Paecilomyces variotii, Purpureocillium lilacinum, and Penicillium species.

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A rare pulmonary infection caused by Arthrographis kalrae

Cited by 21 publications

References 9 publications

Epidemiology and outcomes of invasive fungal infections in allogeneic haematopoietic stem cell transplant recipients in the era of antifungal prophylaxis: a single‐centre study with focus on emerging pathogens

Epidemiology and outcomes of invasive fungal infections in allogeneic haematopoietic stem cell transplant recipients in the era of antifungal prophylaxis: a single‐centre study with focus on emerging pathogens

First case of Arthrographis kalrae fungemia in a patient with cystic fibrosis

Non-Aspergillus Hyaline Molds: Emerging Causes of Sino-Pulmonary Fungal Infections and Other Invasive Mycoses

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