We report the case of an infant who presented with respiratory distress at the Emergency Department. A chest radiograph showed interposition of colon loops between the right hemidiaphragm and liver, while abdominal and thoracic ultrasound examinations were normal. The aforementioned radiological finding was considered to be Chilaiditi's sign. This sign usually presents as an incidental radiological finding and may be mistaken for a pneumoperitoneum or a diaphragmatic hernia. Clinicians' familiarity with rare radiological signs is necessary.