Solitary rectal ulcer syndrome (SRUS) is a chronic benign disease with an unclear pathogenesis and a wide range of macroscopic changes of rectal and sigmoid colon wall, without any specific clinical symptoms. Its detection and differential diagnosis with tumors and inflammatory bowel disease often is challenging. The aim was to assess the entire spectrum of SRUS manifestations, as well as to analyze the possibilities of ultrasound and other imaging modalities (barium enema, defecography, MRI, CT) in its diagnostics. Clinical cases showed that every method solves its own tasks, revealing structural and/or functional changes in SRUS, and makes a valuable contribution to the final diagnosis