A Rat Model of Restrictive Bariatric Surgery with Gastric Banding

Monteiro, Mariana P.; Monteiro, Juliana; Águas, Artur P.; Cardoso, Maria Helena

doi:10.1381/096089206775222159

Cited by 16 publications

(20 citation statements)

References 18 publications

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“…For that, we have used obese Zucker rats ( fa/fa) submitted to bariatric surgery with gastric banding and compared them to two groups of sham-operated animals, one fed ad libitum and another food-restricted to the same amount eaten by the gastric banded animals (pair-fed). Rat gastric banding was herein performed according to a surgical procedure that we have recently introduced and applied to lean Wistar rats [27,28].…”

Section: Discussionmentioning

confidence: 99%

“…Prophylactic antibiotherapy consisting of 1.25 mg ampicillin (Cilin, Quimedical) plus 1.25 mg flucloxacillin (Floxapen, GSK) diluted in 1 ml of sterile water was administered intraperitoneally and immediately before surgery. The surgical technique for gastric banding and sham surgery was performed as previously described for the Wistar rat [28]. Briefly, a midline abdominal incision was made and the stomach exposed to insert a 14-mm-long and 2-mm-wide silicon band, custom-made, at the glandular portion of the gastric fundus immediately below the rumen, partially restraining the stomach volume and creating upper and lower pouches in the stomach.…”

Section: Gastric Bandingmentioning

confidence: 99%

“…After having established an animal model of gastric banding in the normal weight Wistar rat [27,28], our aim now was to apply the same surgical procedure to an obese animal and to investigate the metabolic and endocrine changes induced by gastric banding in the obese Zucker rat.…”

Section: Introductionmentioning

confidence: 99%

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Increase in Ghrelin Levels After Weight Loss in Obese Zucker Rats is Prevented by Gastric Banding

et al. 2007

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Background Gastric banding is thought to decrease appetite in addition to the mechanical effects of food restriction, although this has been difficult to demonstrate in human studies. Our aim was to investigate the changes in orexigenic signals in the obese Zucker rat after gastric banding. Methods Obese Zucker rats ( fa/fa) were submitted to gastric banding (GBP), sham gastric banding fed ad libitum (sham), or sham operation with food restriction, pair-fed to the gastric banding group (sham-PF). Lean Zucker rats ( fa/+) were used as additional controls. Body weight and food intake were daily recorded for 21 days after surgery when epididymal fat was weighed and fasting ghrelin and hypothalamic NPY mRNA expression were measured. Results Gastric banding in obese Zucker rats resulted in a significant decrease of cumulative body weight gain and food intake. Furthermore, gastric banded rats were leaner than Sham-PF, as expressed by a significantly lower epididymal fat weight. Ghrelin levels of gastric banded rats were not increased when compared to sham-operated animals fed ad libitum and were significantly lower than the levels of weight matched sham-PF rats (1116.9±103.3 g GBP vs 963.2±54.3 g sham, 3,079.5±221.6 sham-PF and 2,969.9±150.9 g lean rats, p<0.001); hypothalamic NPY mRNA expression was not increased in GBP when compared to sham-operated rats. Conclusion In obese Zucker rats, GBP prevents the increase in orexigenic signals that occur during caloric deprivation. Our data support the hypothesis that sustained weight loss observed after gastric banding does not depend solely on food restriction.

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Section: Discussionmentioning

confidence: 99%

Section: Gastric Bandingmentioning

confidence: 99%

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Increase in Ghrelin Levels After Weight Loss in Obese Zucker Rats is Prevented by Gastric Banding

et al. 2007

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“…The surgical technique for gastric banding and sham surgery was performed as previously described. 12 Both groups of animals were given 5 ml of sterile warmed saline subcutaneously to avoid dehydration and allowed to recover spontaneously from anesthesia and surgery. Rats were returned to their home cages which contained a pre-weighed amount of food.…”

Section: Gastric Bandingmentioning

confidence: 99%

“…[8][9][10][11] After being submitted to restrictive procedures, patients report a new experience of fullness and a reduction in their hunger sensation. 8,11 After having recently established a rat model of bariatric surgery with gastric banding, 12 we have now investigated the eating patterns displayed by Wistar rats submitted to gastric banding in comparison with those of sham-operated rats, and we have also monitored changes in relative fat mass content of the rats.…”

Section: Introductionmentioning

confidence: 99%

Rats Submitted to Gastric Banding are Leaner and Show Distinctive Feeding Patterns

Monteiro¹,

Monteiro²,

Águas³

et al. 2006

obes surg

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Background: Bariatric surgery is expanding to meet the global epidemic of morbid obesity, because this surgery is successful in achieving sustained weight loss. After having recently established a rat model of gastric banding, our aim now was to investigate the relative fat mass content and the feeding patterns of gastric banded rats.Methods: Two groups of Wistar rats, submitted either to gastric banding or to sham surgery, were followed-up for 26 days regarding weight, daily food intake and feeding patterns both under resting conditions and when refed after fasting. Weight of the epididymal fat pad was used as a measure to evaluate changes in white adipose tissue in the rats.Results: 10 days after surgery and thereafter, rats submitted to gastric banding showed the same daily food intake that was observed in sham-operated rats. Nevertheless, gastric banded rats kept lower body weights and were leaner than controls. These differences were associated with distinctive feeding patterns, both under resting conditions and when refed after fasting, suggesting that gastric banded rats present a significant increase in feeding frequency when compared with controls.Conclusion: This data is the first experimental evidence that an increase in feeding frequency is associated with weight loss after gastric banding, even if there is no decrease in total energy intake. Thus, medical advice on the advantages of fractionating daily caloric intake into multiple meals is further supported by the herein new information obtained in an animal model of gastric banding.

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Bone Metabolism After Bariatric Surgery

2014

Journal of Bone and Mineral Research

186

138

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Bariatric surgery is a popular and effective treatment for severe obesity, but may have negative effects on the skeleton. This review summarizes changes in bone density and bone metabolism from animal and clinical studies of bariatric surgery, with specific attention to Roux-en-Y gastric bypass (RYGB), adjustable gastric banding (AGB), and sleeve gastrectomy (SG). Skeletal imaging artifacts from obesity and weight loss are also considered. Despite challenges in bone density imaging, the preponderance of evidence suggests that bariatric surgery procedures have negative skeletal effects that persist beyond the first year of surgery, and that these effects vary by surgical type. The long-term clinical implications and current clinical recommendations are presented. Further study is required to determine mechanisms of bone loss after bariatric surgery. Although early studies focused on calcium/vitamin D metabolism and mechanical unloading of the skeleton, it seems likely that surgically-induced changes in the hormonal and metabolic profile may be responsible for the skeletal phenotypes observed after bariatric surgery.

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A Rat Model of Restrictive Bariatric Surgery with Gastric Banding

Cited by 16 publications

References 18 publications

Increase in Ghrelin Levels After Weight Loss in Obese Zucker Rats is Prevented by Gastric Banding

Increase in Ghrelin Levels After Weight Loss in Obese Zucker Rats is Prevented by Gastric Banding

Rats Submitted to Gastric Banding are Leaner and Show Distinctive Feeding Patterns

Bone Metabolism After Bariatric Surgery

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