A ratiometric fluorescent probe for detection of exogenous mitochondrial SO₂ based on a FRET mechanism

Abstract

A novel imidazo[1,5-a]pyridine-hemicyanine based ratiometric fluorescent probe for detection of mitochondrial SO2 was designed and synthesized.

A Multifunctional MOF-on-MOF-Based Dual-Channel Luminescent Signal Readout Strategy for Classifying Phenylglyoxylic Acid and 2,6-Dipicolinic Acid

“…9−11 Although there are some chemosensors showing ratiometric responses, most of them rely on significant change in the fluorescence intensity of one and a small change in the fluorescence intensity of the other, which is less sensitive and does not contribute to the improvement of selectivity. 12,13 In this context, the design of dual-responsive probes based on the dual-emissive materials is meaningful, which can not only maintain the excellently selective sensing performance of individual probe, but also further enhance the sensitivity by self-calibration of two different emission peaks. 14,15 Metal− organic frameworks (MOFs) have recently emerged to be a much-talked-about topic owing to their tunable luminescent properties.…”

Imidazo[1,5-a]pyridine-Based Fluorescent Probes: A Photophysical Investigation in Liposome Models

“…The synthesis is straightforward and can be achieved by different approaches in an easily up-scalable manner [4][5][6][7]. Imidazo [1,5-a]pyridine compounds can be used as (i) candidates in medicinal chemistry [8,9]; (ii) ligands for a plethora of coordination complexes [10,11]; (iii) chemical sensors [12,13]; (iv) smart materials in optoelectronics [3,14]; and (v) fluorophores for bioimaging [15][16][17]. In particular, the study of the membrane dynamics in living cells led to the development of many fluorescent probes based on different action strategies (e.g., solvatochromic compounds, flippers) [18][19][20].…”

A turn-on fluorescent probe based on indolizine for the detection of sulfite

“…Numerous SO 3 2− /HSO 3 − fluorescent probes have been reported based on various mechanisms, such as deprotection, 10–13 coordination, 14,15 Michael additions, 16–20 and reaction with aldehyde 21–33 because of their high sensitivity, short response time, good selectivity, and simple operation. However, most probes are constructed from classic dyes such as coumarin, 34,35 BODIPY, 36 and cyanine.…”