A rational design, synthesis, characterization, and antihypertensive activities of some new substituted benzimidazoles

Jain, Arpit; Sharma, Rajesh; Chaturvedi, S. C.

doi:10.1007/s00044-012-0462-7

Cited by 28 publications

(11 citation statements)

References 23 publications

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“…The maximum activity that is almost equipotent with losartan is observed with four compounds 222(a-d) (236). A series of benzimidazole-biphenyl carboxylic acid were synthesized and evaluated for antihypertensive activity direct and indirect methods.…”

Section: Antihypertensive Agentsmentioning

confidence: 99%

“…A series of substituted benzimidazole possessing nitro, amino, alkyl amino, and acyl groups in position 5 were synthesized and evaluated for antihypertensive activity in vivo by acute renal hypertension model. The maximum activity that is almost equipotent with losartan is observed with four compounds 222 ( a – d ) . A series of benzimidazole–biphenyl carboxylic acid were synthesized and evaluated for antihypertensive activity direct and indirect methods.…”

Section: Antihypertensive Agentsmentioning

confidence: 99%

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Comprehensive Review in Current Developments of Benzimidazole‐Based Medicinal Chemistry

et al. 2014

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The properties of benzimidazole and its derivatives have been studied over more than one hundred years. Benzimidazole derivatives are useful intermediates/subunits for the development of molecules of pharmaceutical or biological interest. Substituted benzimidazole derivatives have found applications in diverse therapeutic areas such as antiulcer, anticancer agents, and anthelmintic species to name just a few. This work systematically gives a comprehensive review in current developments of benzimidazole-based compounds in the whole range of medicinal chemistry as anticancer, antibacterial, antifungal, anti-inflammatory, analgesic agents, anti-HIV, antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial, antihistaminic, antimalarial agents, and other medicinal agents. This review will further be helpful for the researcher on the basis of substitution pattern around the nucleus with an aim to help medicinal chemists for developing an SAR on benzimidazole drugs/compounds.

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Section: Antihypertensive Agentsmentioning

confidence: 99%

Section: Antihypertensive Agentsmentioning

confidence: 99%

Comprehensive Review in Current Developments of Benzimidazole‐Based Medicinal Chemistry

et al. 2014

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“…The result of acute renal hypertension showed 106 with total change in systolic BP = 33 mmHg and 107 with EC 50 = 1.81 ± 0.08 µM to be potent antihypertensive agents while 108 bearing ethyl group exhibited better antihypertensive activity than the in vitro AT 1 receptor antagonism . Saczewski and coworkers reported that 109 , had strong binding affinity as well as improved antihypertensive trait while Zhang and coworkers recently evaluated spontaneous hypertensive rats and showed that compound 110 was an orally active AT 1 receptor antagonist with low toxicity and decreased blood pressure by more than 30 mmHg when compared with losartan standard drug .…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Functionalized Benzimidazole Scaffolds: Privileged Heterocycle for Drug Design in Therapeutic Medicine

Ajani

Aderohunmu

Ikpo

et al. 2016

Archiv der Pharmazie

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Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of biologically active compounds which are therapeutically useful agents in drug discovery and medicinal research. They are structural isosteres of naturally occurring nucleotides, which allows them to interact with the biopolymers of living systems. Hence, there is a need to couple the latest information with the earlier documentations to understand the current status of the benzimidazole nucleus in medicinal chemistry research. This present work unveils the benzimidazole core as a multifunctional nucleus that serves as a resourceful tool of information for synthetic modifications of old existing candidates in order to tackle drug resistance bottlenecks in therapeutic medicine. This manuscript deals with the recent advances in the synthesis of benzimidazole derivatives, the widespread biological activities as well as pharmacokinetic reports. These present them as a toolbox for fighting infectious diseases and also make them excellent candidates for future drug design.

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“…It has been applied in plating processes, anticorrosion agents and in the production of composite materials (Chen et al, 2013(Chen et al, , 2014. Trithiocyanuric acid is also used to remove palladium residues from reaction mixtures during the production of drugs (Nile et al, 2013;Krá lová et al, 2013) and as a remediation agent for the removal of heavy metals from industrial wastewaters (Jain et al, 2013;Beaulieu et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Trithiocyanuric acid: novel cocrystals and analysis of its tautomeric forms

Wzgarda-Raj

Rybarczyk‐Pirek

Wojtulewski

et al. 2021

Acta Crystallogr C Struct Chem

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Cocrystals of trithiocyanuric acid with 2,2′-bipyridyl [1,3,5-triazinane-2,4,6-trithione–2,2′-bipyridine (2/1), 2C3H3N3S3·C10H8N2, (I)] and 4-methylbenzohydrazide [1,3,5-triazinane-2,4,6-trithione–4-methylbenzohydrazide (1/1), C8H10N2O·C3H3N3S3, (II)] crystallize in the monoclinic crystal system. In the crystals, molecules of both components are linked by hydrogen bonds. The trithiocyanuric acid molecules are connected by N—H...S hydrogen bonds forming R 2 2(8) synthons, which are further organized into chain motifs. Computations based on quantum chemistry methods have been performed for a more detailed description of the observed tautomerism of trithiocyanuric acid.

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A rational design, synthesis, characterization, and antihypertensive activities of some new substituted benzimidazoles

Cited by 28 publications

References 23 publications

Comprehensive Review in Current Developments of Benzimidazole‐Based Medicinal Chemistry

Comprehensive Review in Current Developments of Benzimidazole‐Based Medicinal Chemistry

Functionalized Benzimidazole Scaffolds: Privileged Heterocycle for Drug Design in Therapeutic Medicine

Trithiocyanuric acid: novel cocrystals and analysis of its tautomeric forms

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